PMID: 8591079Nov 1, 1995Paper

Prognostic factors in resectable gastric cancer: results of EORTC study no. 40813 on FAM adjuvant chemotherapy

Annals of Surgical Oncology
M LiseM Gignoux

Abstract

The high incidence of locoregional recurrences and distant metastases after curative surgery for gastric cancer calls for improved locoregional control and systemic adjuvant treatment. In a randomized clinical trial on adjuvant FAM2 chemotherapy, quality of surgery was evaluated by comparing surgical and pathology data. Univariate and multivariate analysis was made to evaluate the effect of prognostic factors on survival and time of recurrence in relation to patients, tumor, and therapy. Of 314 patients randomized from 28 European institutions, 159 comprised the control and 155 the FAM2 group. After a median follow-up of 80 months, no statistically significant difference was found between survivals. However, for recurrence time, treated patients had a significant advantage over controls (p = 0.02). At univariate analysis, statistically significant differences in survival and time to progression emerged for T, N, disease stage and "adequacy" of surgery. The multivariate analysis retained preoperative Hb level, T, N, and "adequacy" of surgery for time of survival; and T, N, "adequacy" of surgery and adjuvant chemotherapy for recurrence time. Disease stage is the most important prognostic factor. "Adequate" surgery has an importan...Continue Reading

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Citations

Aug 23, 2005·Expert Review of Anticancer Therapy·Gauri Varadhachary, Jaffer A Ajani
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lionel LimTrevor Leong
Jun 10, 2006·Expert Review of Anticancer Therapy·Evangelos BriasoulisAngelos M Kappas
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Atsushi OhtsuNagahiro Saijo
Nov 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D NittiUNKNOWN ICCG

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