Prognostic factors in solitary fibrous tumors of the pleura

The Journal of Surgical Research
Severin SchmidSebastian Wiesemann

Abstract

Solitary fibrous tumors of the pleura (SFTP) are rare neoplasms originating from submesothelial mesenchymal cells with fibroblastic differentiation. The clinical behavior of SFTPs is mostly benign; however, up to 20% of patients develop local recurrence and/or distant metastasis. Although different risk-stratification models have been described, definitive criteria to predict a malignant clinical course of SFTP are still lacking. In a retrospective analysis at a single-institution, 25 patients with histologically proven SFTP were identified. Clinicopathologic and survival data were collected and pathologic sections reviewed. Different markers and risk-stratification models were correlated with disease- and overall-free survival by Kaplan-Meier analysis. Of 25 SFTP, 8 tumors (32%) were classified as malignant according to the World Health Organization criteria. Three patients (12%) developed recurrence. Cohort median follow-up was 28 mo, and median overall survival was 160 mo. Comparison of proliferation markers showed higher mitosis count per high-power field and MIB-1 labeling index (MIB) in malignant compared with nonmalignant SFTP. MIB was identified as a predictor for disease-free survival. Applying the previously reported ...Continue Reading

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Citations

Dec 4, 2015·Revista española de medicina nuclear e imagen molecular·Z TazelerS Tan
May 20, 2015·The Journal of Surgical Research·David McFadden, Wiley W Souba
Aug 25, 2020·ERJ Open Research·Rachel M MercerNajib M Rahman
Dec 6, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marco KrengliJuliette Thariat
Sep 1, 2021·Molecular and Clinical Oncology·Yumiko YamamotoIchiro Murakami

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