Prognostic factors in stereotactic body radiotherapy of lung metastases

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
K J BormMarciana Duma

Abstract

The aim of this study was to evaluate prognostic factors in patients with lung metastases who undergo lung stereotactic body radiotherapy (SBRT). A total of 87 patients with 129 lung metastases who underwent SBRT between November 2004 and May 2012 were enrolled in this retrospective study. The patient collective consisted of 54 men (62.1%) and 33 women (37.9%); the median age was 65 years (range 36-88). The Karnofsky performance index was ≥70% (median 90%) for all cases, but one (60%). Adverse effects were categorized using the CTCAE 4.0 classification system. Retrospective analyses regarding patients' characteristics, progression-free survival (PFS), overall survival (OS), disease-specific survival (DSS), and local tumor control rates (LTC) were performed. On univariate and multivariate analysis OS, DSS, and PFS were significantly (p < 0.05) better for patients with ≤3 lung metastases; no extrathoracic metastases at the time of the SBRT; a gross tumor volume (GTV) <7.7 cm3 and patients that received a staging that included positron emission tomography with fluorine 18 fluorodeoxyglucose/computed tomography (FDG-PET/CT) imaging. Furthermore, a longer OS was observed if newly diagnosed metastases during follow-up were limited to...Continue Reading

References

Oct 31, 2002·The Journal of Thoracic and Cardiovascular Surgery·Yukihito SaitoMasaharu Nakade
Sep 23, 2003·The Journal of Thoracic and Cardiovascular Surgery·Joachim PfannschmidtHendrik Dienemann
Oct 8, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joern WulfMichael P Flentje
Sep 20, 2006·Acta Oncologica·Paul OkunieffMichael C Schell
Nov 28, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Holger HofKlaus Herfarth
Apr 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Yoshiki NorihisaMasahiro Hiraoka
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kyle E RusthovenTracey E Schefter
Apr 8, 2010·Clinical & Experimental Metastasis·Jin-Kyu KangUi-Sup Shin
Jul 6, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Umberto RicardiGiorgio Vittorio Scagliotti
Jan 2, 2013·The Lancet Oncology·Alison C TreeNicholas J van As
Feb 20, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·T InoueH Miura
Mar 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly S CorbinRalph R Weichselbaum
Apr 4, 2014·Radiation Oncology·Pierina NavarriaMarta Scorsetti
Feb 1, 2015·International Journal of Radiation Oncology, Biology, Physics·Joost J NuyttensMischa Hoogeman
Sep 20, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·F De RoseM Scorsetti
Nov 16, 2016·International Journal of Radiation Oncology, Biology, Physics·Juliane RieberMatthias Guckenberger
Feb 9, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S Tanadini-LangM Guckenberger
Mar 4, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Gurleen DhamiStephen R Bowen
Sep 7, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Susanne SteraOliver Blanck

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Citations

Jan 29, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rosario MazzolaFilippo Alongi
Jun 15, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G ChassagnonM-P Revel
Jun 3, 2021·Current Oncology·Brane GrambozovFranz Zehentmayr
Jul 14, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Dorota LubganRainer Fietkau

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