Prognostic factors of brain metastases from colorectal cancer

BMC Cancer
Jun ImaizumiYukihide Kanemitsu

Abstract

For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of brain metastases from colorectal cancer (CRC) other than KPS, this study aimed to identify new prognostic factors. This retrospective cohort study was conducted at a tertiary care cancer center. Subjects were patients with brain metastases from CRC among all patients who received initial treatment for CRC at the National Cancer Center Hospital from 1997 to 2015 (n = 7147). Prognostic clinicopathological variables for overall survival (OS) were investigated. There were 68 consecutive patients with brain metastases from CRC, corresponding to 1.0% of all patients with CRC during the study period. Median survival time was 6.8 months. One-year and 3-year OS rates were 28.0 and 10.1%, respectively. Among the six covariates tested (age, KPS, presence of extracranial metastases, control of primary lesion, number of brain metastases, and history of chemotherapy), multivariate analysis revealed KPS (score ≥ 70), number of brain metastases (1-3), and no history of chemotherapy to be independent factors associated with better prognosi...Continue Reading

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Citations

Jul 18, 2020·Seminars in Cancer Biology·Rui Caetano OliveiraJosé Guilherme Tralhão
Sep 27, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roberto MorettoChiara Cremolini
May 11, 2021·Clinical Colorectal Cancer·Renata Colombo BonadioPaulo M Hoff
Jul 3, 2021·Cancers·Tamara Mc ErlainCristina M Branco

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BETA
surgical resection

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JMP14

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