Prognostic factors of chondroblastic osteosarcoma and nomogram development for prediction: A population-based, STROBE-compliant study.

Medicine
Cheng PengLei Yu

Abstract

The present study aimed to develop nomograms to predict survival in patients with chondroblastic osteosarcoma (COS).An analysis was conducted of 320 cases of COS collected from the surveillance, epidemiology, and end results (SEER) database between 2004 and 2015. Independent prognostic factors were screened using univariate and multivariate Cox analyses. Subsequently, nomograms were established to predict the patients' cancer-specific survival (CSS) and overall survival (OS) rates. The prediction accuracy and discriminative ability of the nomograms were examined using calibration curves and the concordance index (C-index).As revealed in the univariate and multivariate Cox regression analysis, age, tumor size, the primary site, the presence of metastasis, a history of having undergone surgery, and a history of having received radiotherapy were found to be independent prognostic factors associated with survival in patients with COS (all P < .05). Furthermore, age >39 years, the presence of distant metastasis, no history of having undergone any surgery, and tumor size >103 mm were found to be associated with poor prognosis in patients, while the primary site of the mandible and no history of having undergone radiotherapy showed as...Continue Reading

References

Jan 1, 1984·Ultrastructural Pathology·A StarkJ L Ericsson
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P BielingK Winkler
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
Apr 16, 2002·Clinical Orthopaedics and Related Research·Belen Carsi, Michael G Rock
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leo KagerUNKNOWN Cooperative German-Austrian-Swiss Osteosarcoma Study Group
May 15, 2004·Journal of Oral Science·Siew-Tin OngChong-Huat Siar
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Dec 4, 2004·Clinical Orthopaedics and Related Research·Henry J MankinMark C Gebhardt
Jul 25, 2006·Cancer Treatment Reviews·Alessandra LonghiGaetano Bacci
Oct 30, 2007·Journal of Cancer Research and Clinical Oncology·Jonathan C M ClarkPeter F M Choong
Dec 23, 2008·Cancer Biology & Therapy·Mei Lin TanCrispin R Dass
May 9, 2009·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Cody FoxHusain A Saleh
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Jul 5, 2013·The Journal of Bone and Joint Surgery. American Volume·Benjamin J MillerJoseph A Buckwalter
Jun 8, 2017·Oncology Letters·Ye JiangJun Xu
Jun 4, 2019·The Bone & Joint Journal·P TsagozisM C Parry
Nov 2, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shui QiuYue Zhu
Nov 28, 2019·Cancer Control : Journal of the Moffitt Cancer Center·Yue PanZhehao Dai

❮ Previous
Next ❯

Software Mentioned

R
SPSS Statistics
Tile

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.