Prognostic factors of early breast cancer

Medicina clínica
Elena AlmagroE Espinosa

Abstract

Decision about the administration of adjuvant therapy for early breast cancer depends on the evaluation of prognostic factors. Lymph node status, tumor size and grade of differentiation are classical variables in this regard, and can be complemented by hormonal receptor status and HER2 expression. These factors can be combined into prognostic indexes to better estimate the risk of relapse or death. Other factors are less important. Gene profiles have emerged in recent years to identify low-risk patients who can forgo adjuvant chemotherapy. A number of profiles are available and can be used in selected cases. In the future, gene profiling will be used to select patients for treatment with new targeted therapies.

References

Apr 6, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G D'Eredita'F Ferrarese
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen K ChiaIvo A Olivotto
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Aug 27, 2005·The New England Journal of Medicine·Stephan BraunKlaus Pantel
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartHerceptin Adjuvant (HERA) Trial Study Team
Sep 7, 2006·Journal of the National Cancer Institute·Marc BuyseTRANSBIG Consortium
Mar 23, 2007·Breast Cancer Research and Treatment·Isabelle SoerjomataramJan Willem W Coebergh
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherene LoiChristos Sotiriou
May 29, 2008·Journal of the National Cancer Institute·Miguel MartinGEICAM 9906 Study Investigators
Jul 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carey K AndersKimberly L Blackwell
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karl Y BilimoriaDavid J Winchester
Nov 7, 2009·Journal of the National Cancer Institute·Sacha J HowellAnne C Armstrong
Mar 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wolfgang JanniBjørn Naume
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Harold J Burstein
Feb 26, 2013·Journal of Clinical Pathology·Nirmala Pathmanathan, Rosemary L Balleine
Mar 8, 2013·The Surgical Clinics of North America·T Jonathan Yang, Alice Y Ho
Jun 4, 2013·The Lancet Oncology·Viviana Galimberti, Bernard F Cole
Jul 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitch DowsettJack Cuzick
Aug 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BosettiC La Vecchia
Sep 14, 2013·Journal of the National Cancer Institute·Ivana SestakJack Cuzick
Apr 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
May 17, 2014·Journal of the National Cancer Institute·Brigitte RackSUCCESS Study Group
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold J BursteinJennifer J Griggs
Jun 28, 2014·The Oncologist·Maria Vittoria DieciValentina Guarneri
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvia AdamsSunil S Badve
Aug 29, 2014·Breast Cancer Research and Treatment·Lu ChenChristopher I Li

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