Prognostic Factors of Mortality among Adult Patients on Antiretroviral Therapy in India: A Hospital Based Retrospective Cohort Study

BioMed Research International
Nitin JosephPatneedi Sindhu

Abstract

HIV related deaths still continue to occur in large numbers in spite of good quality drugs being freely available in India. This study was therefore done to assess the prognostic factors of mortality among people living with HIV (PLHIV) on antiretroviral therapy (ART). This would help in planning strategies for further improving their survival. Record based data from baseline and follow-up visits of a cohort of patients aged above 14 years on ART was retrospectively reviewed over a seven-year period. The Kaplan-Meier models were used to estimate life time survival probability, and Cox proportional hazard regression model was used to determine independent prognostic factors of death, among patients, after initiation of ART. Mean age of the total 285 patients enrolled in this study was 45.8±9.7 years. Mean duration of treatment on ART was 1127±611.8 days. During the follow-up period, 44/285(15.4%) patients died, resulting in incidence density of death rate as 3.12 per 100 person years. Good adherence with treatment was reported by 267(93.7%) patients. Nearly half of the deaths, i.e., 21(47.7%), occurred within three months of them starting ART. The mean survival time after initiation of ART was 2084.0±55.3 days (95% CI is 1975.5-...Continue Reading

References

Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen D LawnRobin Wood
Nov 20, 2008·Tropical Medicine & International Health : TM & IH·Isidore SieleunouMarleen Boelaert
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Mar 15, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ramesh Reddy AllamSanjay Mehendale

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Citations

Apr 24, 2020·AIDS Research and Human Retroviruses·Akililu Alemu AshuroYin-Guang Fan
Aug 14, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marco FloridiaMaria Cristina Marazzi

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