Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 cases

Cancer
Ronald A GhosseinBhuvanesh Singh

Abstract

Follicular carcinomas of the thyroid gland, including its oncocytic variant (so-called Hurthle cell carcinoma), are subdivided into the indolent encapsulated ("minimally invasive") and the clinically aggressive widely invasive tumors. There are, however, cases of encapsulated follicular carcinoma that recur and metastasize. Identifying these cases at the time of diagnosis is crucial for prognostic and therapeutic considerations. Because to the authors' knowledge most studies do not focus exclusively on the encapsulated Hurthle cell carcinoma (EHC), the current study attempted to identify predictors of recurrence in EHC. A tumor was defined as EHC if it was encapsulated, macroscopically well defined with microscopic but no macroscopic evidence of vascular or capsular invasion, and composed of > 75% follicular oncocytic cells. Retrospective chart review and microscopic examination identified 50 primary tumors meeting the above criteria at the Memorial Sloan-Kettering Cancer Center between 1967 and 2005. The cases were analyzed for various histologic and clinical parameters. Each parameter was correlated with recurrence-free survival (RFS). Seven of 50 (14%) patients developed disease recurrence. All patients who developed recurre...Continue Reading

References

Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·A KawaoiS Moriyama
Mar 1, 1988·Zentralblatt für Veterinärmedizin. Reihe A·A L ParodiF Crespeau
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·S SchröderW Böcker
Nov 1, 1994·Head & Neck·K SegalR Feinmesser
Jun 1, 1996·The American Journal of Surgical Pathology·M PapottiG Bussolati
Dec 16, 1998·The American Journal of Surgical Pathology·H L Evans, R Vassilopoulou-Sellin
Mar 25, 1999·Thyroid : Official Journal of the American Thyroid Association·S LazziH Cottier
Mar 4, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N S GoldsteinJ S Neill
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A StojadinovicB Singh
Jul 13, 2002·Endocrine Pathology·Maria L. Carcangiu
Jul 1, 1954·American Journal of Clinical Pathology·J B HAZARD, R KENYON
Jul 21, 2004·Archives of Otolaryngology--head & Neck Surgery·Carsten E PalmeJeremy L Freeman

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Citations

Nov 20, 2010·Endocrine Pathology·Ronald Ghossein
Mar 1, 2009·Head and Neck Pathology·Ronald Ghossein
Feb 5, 2009·Thyroid : Official Journal of the American Thyroid Association·Michael RiveraRonald A Ghossein
Mar 1, 2012·Pathology International·Kennichi KakudoTakashi Ozaki
Jan 1, 2011·BMJ Case Reports·Mark Anthony S Sandoval, Elizabeth Paz-Pacheco
Jun 15, 2010·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M HermannN Neuhold
Feb 10, 2016·Endocrine·Gustav StensonJan Zedenius
Sep 8, 2010·Journal of Theoretical Biology·Natasha K MartinPhilip K Maini
Nov 5, 2015·Endocrine Pathology·Shuanzeng WeiZubair W Baloch
Dec 17, 2009·Histopathology·Oleksiy Tsybrovskyy, Martina Rössmann-Tsybrovskyy
May 25, 2015·Endocrine Pathology·Bin Xu, Ronald Ghossein
Jan 1, 2013·Endocrinology, Diabetes & Metabolism Case Reports·Mauro BoronatFrancisco J Nóvoa
Mar 10, 2015·Thyroid : Official Journal of the American Thyroid Association·Volkert B WreesmannRonald A Ghossein
May 11, 2016·Thyroid : Official Journal of the American Thyroid Association·James X WuMasha J Livhits
Aug 3, 2016·Thyroid : Official Journal of the American Thyroid Association·Ilya LikhterovMark L Urken
May 18, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·I J NixonD Kim
Jul 20, 2019·Thyroid : Official Journal of the American Thyroid Association·Leila ShobabKenneth D Burman
Aug 10, 2019·Thyroid : Official Journal of the American Thyroid Association·Kristine S WongJustine A Barletta
Sep 27, 2014·The Journal of Clinical Endocrinology and Metabolism·Ana-Maria ChindrisRobert C Smallridge
Apr 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Ian GanlyTimothy A Chan
Mar 23, 2018·Indian Journal of Surgical Oncology·Chitresh KumarSaroj Kanta Mishra
Sep 22, 2018·Endocrine Pathology·Tyler Janovitz, Justine A Barletta
Oct 28, 2020·Cancer Cytopathology·Kristine S WongJeffrey F Krane
Mar 7, 2021·International Journal of Molecular Sciences·Jinwei HuXiangpeng Yuan

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