Prognostic factors of ulcer healing and amputation-free survival in patients with critical limb ischemia

Vascular
Tadashi FuruyamaYoshihiko Maehara

Abstract

A multidisciplinary approach is required to treat critical limb ischemia. We determined the poor prognostic factors of ischemic ulcer healing after optimal arterial revascularization, and assessed the efficacy of the medication therapy using cilostazol, which is a selective inhibitor of phosphodiesterase 3. In this retrospective, single-center, cohort study, 129 limbs that underwent infrainguinal arterial revascularization for Rutherford class 5 critical limb ischemia were reviewed. The primary end point was the ulcer healing time after arterial revascularization. The secondary end point was the amputation-free survival rate. Of the 129 limbs, endovascular therapy was performed in 69 limbs, and surgical reconstructive procedures were performed in 60 limbs for initial therapy. Complete ulcer healing was achieved in 95 limbs (74%). The median ulcer healing time was 90 days. In multivariate analysis, no cilostazol use significantly inhibited ulcer healing ( p = 0.0114). A white blood cell count >10,000 ( p = 0.0185), a major defect after debridement ( p = 0.0215), and endovascular therapy ( p = 0.0308) were significant poor prognostic factors for ulcer healing. Additionally, ischemic heart disease ( p < 0.0001), albumin levels <3 ...Continue Reading

References

Mar 29, 2001·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·P Grove
Oct 8, 2003·Current Pharmaceutical Design·Junichi KambayashiFrank Czerwiec
Feb 10, 2009·Surgery Today·Fabio A KudoToshiya Nishibe
Feb 17, 2009·Journal of Vascular Surgery·Mark E O'DonnellChee V Soong
Aug 20, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A HoriK Komori
Dec 20, 2011·Annals of Vascular Surgery·Bjoern D SuckowUNKNOWN Vascular Study Group of New England
Jan 13, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N AzumaT Sasajima
Dec 12, 2012·Journal of Vascular Surgery·Maria SöderströmMaarit Venermo
May 4, 2013·Annals of Vascular Diseases·Kou InoToshihiro Onohara
May 16, 2013·International Wound Journal·Stefano de FranciscisRaffaele Serra
Jun 26, 2013·Journal of Internal Medicine·M A Lambert, J J F Belch
Sep 3, 2013·Journal of Vascular Surgery·Jayer ChungR James Valentine
Jan 29, 2014·Journal of Vascular Surgery·Courtney J WarnerPhilip P Goodney
Jul 8, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyoshi AzumaHisashi Uchida
Jul 31, 2014·Journal of Vascular Surgery·Jayer ChungR James Valentine
Jan 18, 2015·Journal of Vascular Surgery·J David NeelTodd R Vogel

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Citations

Dec 21, 2019·Revista do Colégio Brasileiro de Cirurgiões·Allan Lemos MaiaWendell Ricardo de Medeiros Alves Fernandes
Feb 4, 2022·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Adham M KarimMehdi H Shishehbor

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Methods Mentioned

BETA
amputation

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