PMID: 11927308Apr 3, 2002Paper

Prognostic features of pathologic stage T1 renal cell carcinoma after radical nephrectomy

Urology
Weber K LauHorst Zincke

Abstract

To assess the effect of renal cell carcinoma (RCC) subtype, tumor size, and Fuhrman grade on clinical outcome in patients with pathologic T1 (pT1) RCC treated with radical nephrectomy. Between 1970 and 1998, 840 patients underwent radical nephrectomy for pT1 RCC. Tumors were subtyped and graded. Univariate and multivariate Cox proportional hazards models were fitted to assess the features associated with metastasis-free survival (MFS) and cancer-specific survival (CSS). We identified a range of tumor sizes of clear cell RCC in which a transition occurred from low to high risk. Cox proportional hazards models were then fitted by using size cutoffs. The mean follow-up (+/- SD) was 9.4 +/- 6.6 years among the patients alive at latest follow-up. At 10 years, the CSS and MFS for clear cell RCC (n = 682) were 89.1% and 88.6%, respectively; for papillary RCC (n = 122), they were 95.5% and 93.8%; and for chromophobe RCC (n = 33), they were both 100%. The differences in CSS (P = 0.013) and MFS (P = 0.023) between clear cell RCC and the other subtypes were statistically significant. For clear cell RCC, tumor size and Fuhrman grade were independently associated with CSS and MFS (P <0.001). A transition in risk occurred for tumor sizes bet...Continue Reading

References

May 11, 1976·Urology·W G Johnston, R H Hackler
Jan 1, 1992·Urologia Internationalis·T TsukamotoM Satoh
Jan 1, 1991·Urologia Internationalis·T Strohmeyer, R Ackermann
Nov 1, 1989·Journal of Computer Assisted Tomography·N M RofskyG F Coppa
Jan 1, 1989·European Urology·S StörkelR Lippold
Nov 1, 1989·Urology·L K GreenV F Guinee
Jan 1, 1987·Urologic Radiology·H A MittyS H Dikman
Oct 1, 1982·The American Journal of Surgical Pathology·S A FuhrmanC Limas
Sep 1, 1995·The Journal of Urology·T B CrottyM M Lieber
May 1, 1995·Current Opinion in Oncology·P D Savage
Nov 1, 1993·Journal of Surgical Oncology·W FrankM Rubenstein
Mar 1, 1993·The American Journal of Surgical Pathology·A B GelbL J Medeiros
May 1, 1993·Current Opinion in Oncology·P D Savage
Oct 23, 1997·The American Journal of Surgical Pathology·A A RenshawM R Pins
Apr 29, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·S YoshinoK Okada
Jul 4, 2001·The Journal of Urology·M W KattanP Russo

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Citations

Oct 27, 2006·World Journal of Urology·Phillip M PierorazioJames M McKiernan
Aug 28, 2007·World Journal of Urology·Rosamonde E BanksPeter J Selby
Apr 7, 2010·World Journal of Urology·Alessandro Volpe, Jean Jacques Patard
Feb 15, 2013·Current Oncology Reports·Theodore F Logan
Jan 23, 2003·Current Urology Reports·Kent G Krejci, Bradley C Leibovich
Jan 9, 2007·Journal of Endourology·Sean CollinsJaime Landman
Apr 30, 2003·The American Journal of Surgical Pathology·John C ChevilleMichael L Blute
Dec 4, 2004·The American Journal of Surgical Pathology·Stephen M Bonsib
Jun 5, 2003·Current Opinion in Oncology·Young E Whang, Paul A Godley
Feb 11, 2003·The Journal of Urology·Ken-Ryu HanAie S Belldegrun
Aug 13, 2003·The Journal of Urology·Ganesh S PalapattuArie S Belldegrun
Feb 16, 2005·The Journal of Urology·R Houston ThompsonMichael L Blute
Aug 26, 2006·The American Journal of Surgical Pathology·Dianne Sika-PaotonuBrett Delahunt
Dec 30, 2004·Journal of Clinical Pathology·S Fleming, D F R Griffiths
Dec 30, 2004·Journal of Clinical Pathology·V ForiaD N Poller
Feb 21, 2004·AJR. American Journal of Roentgenology·Raymond M HsuStanley S Siegelman
Nov 1, 2011·Chinese Journal of Cancer·Zhi-Ling ZhangFang-Jian Zhou
Nov 16, 2010·The Journal of Urology·Amaka T FadahunsiGennady Bratslavsky
Sep 5, 2015·Clinical Genitourinary Cancer·Alessandro VolpeCarlo Terrone
Nov 11, 2008·The Urologic Clinics of North America·Brian R Lane, Michael W Kattan
Sep 2, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M CrépelJ-J Patard
Apr 29, 2008·Cancer Treatment Reviews·D FurnissUNKNOWN National Cancer Research Institute Renal Clinical Studies Group
May 20, 2008·The Journal of Urology·Jens BedkeMarkus Hohenfellner
May 20, 2008·The Journal of Urology·Aaron JohnsonGennady Bratslavsky
Oct 13, 2007·Critical Reviews in Oncology/hematology·John S LamRobert A Figlin
Aug 19, 2007·Regulatory Peptides·Gorka LarrinagaAdolfo Varona
Oct 7, 2005·Cancer·Vincenzo FicarraJean-Jacques Patard
Apr 20, 2007·BJU International·Paul L Crispen, Robert G Uzzo
Aug 20, 2008·BJU International·Melissa A LaudanoJames M McKiernan

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