Prognostic impact of average iodine density assessed by dual-energy spectral imaging for predicting lung tumor recurrence after stereotactic body radiotherapy

Journal of Radiation Research
Masahiko AokiYoshihiro Takai

Abstract

The purpose of this study was to investigate the prognostic significance of average iodine density as assessed by dual-energy computed tomography (DE-CT) for lung tumors treated with stereotactic body radiotherapy (SBRT). From March 2011 to August 2014, 93 medically inoperable patients with 74 primary lung cancers and 19 lung metastases underwent DE-CT prior to SBRT of a total dose of 45-60 Gy in 5-10 fractions. Of these 93 patients, nine patients had two lung tumors. Thus, 102 lung tumors were included in this study. DE-CT was performed for pretreatment evaluation. Regions of interest were set for the entire tumor, and average iodine density was obtained using a dedicated imaging software and evaluated with regard to local control. The median follow-up period was 23.4 months (range, 1.5-54.5 months). The median value of the average iodine density was 1.86 mg/cm(3) (range, 0.40-9.27 mg/cm(3)). Two-year local control rates for the high and low average iodine density groups divided by the median value of the average iodine density were 96.9% and 75.7% (P = 0.006), respectively. Tumors with lower average iodine density showed a worse prognosis, possibly reflecting a hypoxic cell population in the tumor. The average iodine density ...Continue Reading

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Citations

Mar 27, 2020·Investigative Radiology·Hatem Alkadhi, André Euler
Jun 12, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Cherry KimKi Yeol Lee
Jul 28, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Hironori ShimamotoShinji Naganawa
Jan 28, 2021·Diagnostics·Masakatsu TsurusakiMasatoshi Kudo
Jan 9, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Shingo IwanoShinji Naganawa
Feb 4, 2021·European Journal of Radiology Open·Amit GuptaKai R Laukamp

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