PMID: 8606275Mar 1, 1996Paper

Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure

Journal of the American College of Cardiology
R PacherG Maurer

Abstract

This study sought to test the hypothesis that big endothelin-1 plasma levels in advanced heart failure are related to survival. In heart failure, production of the potent vasoconstrictor endothelin-1 is increased. Because elevation of immunoreactive endothelin-1 in severe heart failure is primarily related to the precursor "big" endothelin-1, increased big endothelin-1 levels may be associated with a poor prognosis. Plasma big endothelin-1 concentrations, in addition to 16 clinical, hemodynamic and neurohumoral variables, were obtained from 113 patients (mean age -=/[SEM] 53 +/- 1 years) with left ventricular ejection fraction <20% and were related to 1-year mortality by a stepwise Cox regression multivariate analysis. Plasma big endothelin-1 concentrations were significantly higher in patients with moderate and severe heart failure than in those with mild heart failure (4.5 +/- 0.4 and 6.0 +/- 0.1 vs. 2.7 +/- 0.1 fmol/ml, p = 0.0001, respectively) and lower in 58 one-year survivors than in 29 nonsurvivors (2.6 +/- 0.1 vs. 5.9 +/- .04 fmol/ml, p = 0.0001) and 26 heart transplant recipients. By univariate analysis, big endothelin-1 plasma concentrations (p < 0.0001), functional class, daily furosemide dose, left ventricular ejec...Continue Reading

References

Aug 11, 1992·Mayo Clinic Proceedings·R J RodehefferJ C Burnett
Apr 1, 1992·European Journal of Clinical Investigation·O F WagnerW Waldhäusl
Apr 1, 1992·Circulation·J J McMurrayJ J Morton
Feb 1, 1992·American Heart Journal·J ParameshwarP A Poole-Wilson
Oct 15, 1991·The American Journal of Cardiology·M HiroeF Marumo
Nov 1, 1990·Mayo Clinic Proceedings·A LermanJ C Burnett
Jun 1, 1989·Journal of the American College of Cardiology·S S GottliebM Packer
Jan 1, 1989·The Journal of Clinical Investigation·W L MillerJ C Burnett
Jun 15, 1989·Biochemical and Biophysical Research Communications·J PernowJ M Lundberg
Jan 1, 1987·Circulation·J G CopelandS M Nicholson
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Jun 15, 1995·The American Journal of Cardiology·H KrumM Packer
Apr 1, 1994·Circulation·C M WeiJ C Burnett

❮ Previous
Next ❯

Citations

Nov 30, 2000·Clinical Cardiology·S H EllahhamW K Choucair
Sep 18, 2010·Cellular and Molecular Life Sciences : CMLS·Yoshifumi Kawanabe, Surya M Nauli
Sep 12, 2000·Current Hypertension Reports·G Sütsch, M Barton
Jan 11, 2003·The American Journal of Cardiology·Doron Aronson, Andrew J Burger
May 4, 2001·The American Journal of Medicine·K F Adams
Feb 19, 1999·Lancet·A Benigni, G Remuzzi
Sep 6, 2000·Trends in Pharmacological Sciences·F D Russell, P Molenaar
Jun 4, 1999·Trends in Pharmacological Sciences·T Miyauchi, K Goto
Jan 20, 2004·International Journal of Cardiology·L SpinarováJ Tomandl
May 14, 1998·International Journal of Cardiology·E OechslinW Kiowski
Sep 18, 1998·International Journal of Cardiology·L SpinarováM Stejfa
Jun 11, 1999·International Journal of Cardiology·P UusimaaK Peuhkurinen
May 10, 2001·Journal of the American College of Cardiology·L E SpiekerT F Lüscher
May 22, 2002·Journal of the American College of Cardiology·Wendy JohnsonLynne W Stevenson
May 14, 2003·Journal of the American College of Cardiology·Stephen S Gottlieb
Oct 13, 1998·Journal of the American College of Cardiology·P de GrooteJ M Lablanche
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Robert P. OstrowskiAndrzej Kapuściński
Dec 20, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul WexbergDietmar Glogar
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rudolf BergerRichard Pacher
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeanette Strametz-JuranekBrigitte Stanek
Jan 22, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jutta Bergler-KleinBrigitte Stanek
Mar 7, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R BergerB Stanek
Dec 4, 2002·Nature Reviews. Drug Discovery·Giuseppe RemuzziAriela Benigni
Jul 25, 2000·European Journal of Clinical Investigation·A Martínez-RubioJ O Llanos
Aug 19, 1999·The New England Journal of Medicine·R W Schrier, W T Abraham
Jun 2, 2001·The New England Journal of Medicine·M PackerUNKNOWN Carvedilol Prospective Randomized Cumulative Survival Study Group
Apr 26, 2003·Heart Disease·Judy W M Cheng
Feb 12, 2009·Clinical and Experimental Pharmacology & Physiology·Jer-Young LiouJu-Chi Liu
Feb 22, 2005·Congestive Heart Failure·Andrew J Burger
Apr 1, 1999·Annual Review of Physiology·T Miyauchi, T Masaki
Jan 11, 2003·Journal of Clinical Pharmacology·Paul L M van GiersbergenJasper Dingemanse
Dec 1, 2001·Biological & Pharmaceutical Bulletin·K Goto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.