Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma.

Oncotarget
Ling LiKen H Young

Abstract

Dysregulated NF-κB signaling is critical for lymphomagenesis. The regulation, function, and clinical relevance of c-Rel/NF-κB activation in diffuse large B-cell lymphoma (DLBCL) have not been well studied. In this study we analyzed the prognostic significance and gene-expression signature of c-Rel nuclear expression as surrogate of c-Rel activation in 460 patients with de novo DLBCL. Nuclear c-Rel expression, observed in 137 (26.3%) DLBCL patients frequently associated with extranoal origin, did not show significantly prognostic impact in the overall- or germinal center B-like-DLBCL cohort, likely due to decreased pAKT and Myc levels, up-regulation of FOXP3, FOXO3, MEG3 and other tumor suppressors coincided with c-Rel nuclear expression, as well as the complicated relationships between NF-κB members and their overlapping function. However, c-Rel nuclear expression correlated with significantly poorer survival in p63+ and BCL-2- activated B-cell-like-DLBCL, and in DLBCL patients with TP53 mutations. Multivariate analysis indicated that after adjusting clinical parameters, c-Rel positivity was a significantly adverse prognostic factor in DLBCL patients with wild type TP53. Gene expression profiling suggested dysregulations of cel...Continue Reading

References

Jul 1, 1993·Genes & Development·M L ScottD Baltimore
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Aug 5, 2003·Molecular and Cellular Biology·Arnaud ParcellierCarmen Garrido
May 4, 2004·Nature Reviews. Cancer·Julian Adams
Dec 4, 2004·Nature·Ryan T Phan, Riccardo Dalla-Favera
Nov 2, 2005·Molecular and Cellular Biology·Mariano J ScianSumitra Deb
Dec 31, 2005·Genes & Development·David KashatusAlbert S Baldwin
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen BuntingM Frances Shannon
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong-Chen LuPamela S Ohashi
Aug 12, 2009·Journal of Hematopathology·Choladda V CurryChung-Che Chang
Aug 29, 2009·Science·Wei-Lei YangHui-Kuan Lin
Dec 10, 2009·The Journal of Experimental Medicine·Iwao IsomuraSteve Gerondakis
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Louis M Staudt
Jul 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guobing ChenM Frances Shannon
Aug 4, 2010·The International Journal of Biochemistry & Cell Biology·Hiroto KatohYang Liu
Apr 15, 2011·PloS One·Louiza LoizouAlexander G Betz
Aug 13, 2011·Nucleic Acids Research·Stefano AmenteBarbara Majello
Dec 31, 2011·Genes & Cancer·Thomas D Gilmore, Steve Gerondakis
Jan 10, 2012·Annual Review of Immunology·Arthur L ShafferLouis M Staudt
Sep 18, 2012·Cell Cycle·Irene López-MateoBorja Belandia
Oct 10, 2012·American Journal of Hematology·Sonia FabrisAntonino Neri

❮ Previous
Next ❯

Citations

Jun 9, 2016·Advances in Anatomic Pathology·Penelope KorkolopoulouMaria Ioannou
Jul 2, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ruifang SunKen H Young
Jul 7, 2019·Cancers·Maike Kober-Hasslacher, Marc Schmidt-Supprian
May 28, 2019·Nature Reviews. Clinical Oncology·Yi MiaoKen H Young
Jul 10, 2019·Molecular Carcinogenesis·Kathryn E KingWendy C Weinberg
Jan 15, 2020·Analytical Cellular Pathology (Amsterdam)·Alexandra Ioana CioroianuFlorica Staniceanu
Aug 8, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhiyu LiuKen H Young
Mar 5, 2020·Cellular and Molecular Life Sciences : CMLS·Shrikanth C Basavarajappa, Parameswaran Ramakrishnan
Jan 10, 2019·Journal of Cellular Physiology·Keywan MortezaeeAmirhossein Sahebkar
Jan 13, 2016·British Journal of Cancer·Jill E HunterNeil D Perkins
Nov 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zijun Y Xu-MonetteKen H Young
May 24, 2017·International Journal of Oncology·Fang-Yi FanYi Su
Mar 20, 2020·The Journal of Clinical Investigation·Maike Kober-HasslacherMarc Schmidt-Supprian
Feb 6, 2020·Anti-cancer Agents in Medicinal Chemistry·Feifei SunXin Wang
Mar 11, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Qingqing CaiKen H Young
Jun 20, 2017·The American Journal of Pathology·Jinfen WangKen H Young
May 8, 2021·Frontiers in Oncology·Nathalie FaumontJean Feuillard

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
deubiquitination
coimmunoprecipitation
biopsy

Software Mentioned

GEP
Ingenuity Pathway Analysis
SPSS
GraphPad Prism

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.