Prognostic impact of CD4-positive T cell subsets in early breast cancer: a study based on the FinHer trial patient population

Breast Cancer Research : BCR
Marcus SchmidtH Joensuu

Abstract

The clinical importance of tumor-infiltrating cluster of differentiation 4 (CD4) T cells is incompletely understood in early breast cancer. We investigated the clinical significance of CD4, forkhead box P3 (FOXP3), and B cell attracting chemokine leukocyte chemoattractant-ligand (C-X-C motif) 13 (CXCL13) in early breast cancer. The study is based on the patient population of the randomized FinHer trial, where 1010 patients with early breast cancer were randomly allocated to adjuvant chemotherapy containing either docetaxel or vinorelbine, and human epidermal growth factor receptor 2 (HER2)-positive patients were also allocated to trastuzumab or no trastuzumab. Breast cancer CD4, FOXP3, and CXCL13 contents were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR), and their influence on distant disease-free survival (DDFS) was examined using univariable and multivariable Cox regression and Kaplan-Meier estimates in the entire cohort and in selected molecular subgroups. Interactions between variables were analyzed using Cox regression. The triple-negative breast cancer (TNBC) subset of the HE10/97 randomized trial was used for confirmation. High CXCL13 was associated with favorable DDFS in univariable analys...Continue Reading

References

Oct 7, 2004·International Immunology·Haruhiko YagiShimon Sakaguchi
Jul 13, 2005·Cancer Immunology, Immunotherapy : CII·K L Knutson, M L Disis
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gaynor J BatesAlison H Banham
Jul 3, 2008·Cancer Research·Marcus SchmidtMathias Gehrmann
Mar 26, 2009·Cancer Research·Marcus SchmidtMathias C Gehrmann
Oct 10, 2009·Journal of the National Cancer Institute·Richard M SimonDaniel F Hayes
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heikki JoensuuPirkko-Liisa Kellokumpu-Lehtinen
Jun 18, 2010·Breast Cancer Research and Treatment·Sahar M A MahmoudAndrew R Green
Sep 2, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giampaolo BianchiniLajos Pusztai
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sahar M A MahmoudAndrew R Green
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Jul 9, 2011·Nature Immunology·Stephen L Nutt, David M Tarlinton
Oct 8, 2011·Breast Cancer Research : BCR·Achim RodyManfred Kaufmann
Feb 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcus SchmidtJan G Hengstler
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jun 20, 2013·The Journal of Clinical Investigation·Chunyan Gu-TrantienKaren Willard-Gallo
Feb 1, 2014·The Lancet Oncology·Giampaolo Bianchini, Luca Gianni
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvia AdamsSunil S Badve
Dec 24, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carsten DenkertSibylle Loibl
Apr 4, 2015·Science·Ton N Schumacher, Robert D Schreiber
Apr 23, 2015·Nature·Sebastian KreiterUgur Sahin
Jul 21, 2015·Nature Medicine·Andrew J GentlesAsh A Alizadeh
Oct 16, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X YuJ Huang
May 4, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Samantha BuruguTorsten O Nielsen
May 4, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rita NandaLaurence Buisseret
Mar 3, 2017·Journal of Cancer Research and Clinical Oncology·Anne-Sophie HeimesM Schmidt
Jun 2, 2017·JCI Insight·Chunyan Gu-TrantienKaren Willard-Gallo
Jun 7, 2017·Breast Cancer Research and Treatment·A-S HeimesM Schmidt

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Citations

Nov 27, 2018·Expert Opinion on Investigational Drugs·Anne-Sophie Heimes, Marcus Schmidt
Dec 14, 2019·Current Opinion in Obstetrics & Gynecology·Marcus Schmidt
Jul 30, 2019·Frontiers in Endocrinology·Marcelo G KazanietzMariana Cooke
Aug 25, 2020·Journal Für Gynäkologische Endokrinologie·Marcus Schmidt
Jul 1, 2020·Cancers·Sabina SanegreTomás Álvaro Naranjo
Mar 31, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tsengelmaa JamiyanMitsuhiro Hayashi
Oct 3, 2020·International Journal of Molecular Sciences·Anne-Sophie HeimesMarcus Schmidt
Jan 28, 2021·Cells·Maria Vittoria DieciValentina Guarneri
Sep 8, 2020·Clinical Breast Cancer·Stephanie L Goff, David N Danforth
Nov 5, 2020·International Journal of Molecular Sciences·Giovanni ZarrilliMatteo Fassan
Jan 21, 2021·Cancer Management and Research·Jie Zhang, Dawei Hu
Nov 7, 2020·International Journal of Molecular Sciences·Sören SchnellhardtLuitpold Distel
Jul 25, 2021·Cancers·Marcus SchmidtHeikki Joensuu

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Methods Mentioned

BETA
confocal microscopy

Clinical Trials Mentioned

ISRCTN76560285

Software Mentioned

Statistical Package for Social Science ( SPSS ) (
FinHER
GeparSixto

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