Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas.

BMC Clinical Pathology
Sveinung W SorbyeLill-Tove Busund

Abstract

Prognostic markers in curable STS may have the potential to guide therapy after surgical resection. The purpose of this study was to clarify the prognostic impact of the presence of cells and growth factors belonging to the innate immune system in soft tissue sarcomas (STS). The significance of macrophages (CD68), their growth factor macrophage colony-stimulating factor (M-CSF), its receptor colony-stimulating factor-1 receptor (CSF-1R), natural killer cells (CD57) and the general immunomodulating molecule (TGF-beta) are all controversial in STS. Herein, these markers are evaluated and compared to the cell proliferation marker Ki67. Tissue microarrays from 249 patients with non-gastrointestinal (non-GIST) STS were constructed from duplicate cores of viable and representative neoplastic tumor areas and duplicate cores of peritumoral capsule. Immunohistochemistry was used to evaluate the expression of CD68, M-CSF, CSF-1R, CD57, TGF-beta and Ki67 in tumor and peritumoral capsule. In univariate analyses increased expression of M-CSF (P = 0.034), Ki67 (P < 0.001) and TGF-beta (P = 0.003) in tumor correlated with shorter disease-specific survival (DSS). Increased expression of CD68 in tumor correlated significantly with malignancy gr...Continue Reading

References

Dec 1, 1990·Histopathology·D C Brown, K C Gatter
Oct 29, 2000·International Journal of Impotence Research·P GonteroG H Muir
Mar 10, 2001·Experimental Cell Research·J W Rocco, D Sidransky
Mar 21, 2001·Human Molecular Genetics·O P KallioniemiG Sauter
Jun 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·I TakanamiM Giga
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·A NocitoG Sauter
Dec 26, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Francisco R VillegasLuis Callol
Mar 1, 2002·Current Opinion in Immunology·Mark J SmythDale I Godfrey
Mar 14, 2002·Expert Opinion on Biological Therapy·Michael L Salgaller
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M BremnesW A Franklin
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Márta KorbonitsAshley B Grossman
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andre M OliveiraRicardo V Lloyd
Apr 16, 2003·Gynecologic Oncology·Gregg van de PutteGunnar B Kristensen
May 8, 2003·Annals of Surgical Oncology·Jonathan B KoeaMurray F Brennan
Jan 9, 2004·Advances in Cancer Research·Jun Wu, Lewis L Lanier
Nov 3, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S R GrobmyerS Singer
Jul 9, 2005·Cancer·William M MendenhallWilliam G Cance
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hsuan-Ying HuangChing-Yeh Hsiung
Mar 7, 2006·Cell Metabolism·Angelina RodriguezJorge Moscat
Apr 22, 2006·ANZ Journal of Surgery·Ian C DickinsonPeter Steadman
Sep 5, 2006·Molecular Cell·Jorge MoscatSonsoles Campuzano
Jun 1, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Muna SabahElaine Kay
Sep 6, 2007·Molecular and Cellular Biology·Karina UmanskayaDoris Germain
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tom DonnemRoy M Bremnes
Jul 30, 2008·Cell·Joan Massagué
Dec 3, 2008·Cancer Research·Sarasija NainiCorinne M Linardic
Apr 3, 2009·Cancer Research·Koichi NishijoCharles Keller

❮ Previous
Next ❯

Citations

Mar 19, 2013·BMC Clinical Pathology·Sveinung W SorbyeLill-Tove Busund
Oct 9, 2013·Cancer Immunology, Immunotherapy : CII·Dmitriy W Gutkin, Michael R Shurin
Nov 28, 2015·Thoracic Surgery Clinics·Michael A Morse
Apr 29, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maurizio GhisoliJohn Nemunaitis
Nov 12, 2014·Molecular Medicine Reports·Lian Tao LiJun Nian Zheng
Dec 29, 2019·BMC Bioinformatics·Barbara Rita BarricelliBarbara Vergani
Jan 30, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Azadeh ElmiDavid A Mankoff

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
PCR
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.