PMID: 15367886Sep 16, 2004Paper

Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma

Pancreas
M NiedergethmannR Hildenbrand

Abstract

The cysteine proteases cathepsin B (CTSB) and L (CTSL) have been implicated in tumor spread and metastatic formation. In pancreatic adenocarcinoma, the role of these proteases is not very well defined. To find out which cell types produce CTSB and CTSL and to evaluate the prognostic impact of these proteases, 70 specimens from curatively resected patients with pancreatic adenocarcinoma were examined by in situ hybridization and immunohisto-chemistry. Seventy patients with ductal adenocarcinoma of the pancreas were studied after R0 resection with a follow-up of at least 3 years. CTSB and CTSL expression was performed immunohisto-chemically using polyclonal anti-CTSB and CTSL antibodies. To detect cell types involved in producing CTSB and CTSL as well as the intracellular localization of specific mRNA sequences, nonisotopic in situ hybridization was performed. The correlations among CTSB and CTSL expression, clinicopathologic parameters, and clinical outcome were analyzed. The immunoreactivity was 96% for CTSB and 90% for CTSL. Positive mRNA signals were obtained in the cytoplasm tumor cells, macrophages, and fibroblasts in 77% for CTSB and 81% for CTSL, respectively. Statistical analysis showed a significant correlation between ...Continue Reading

References

May 1, 1992·Clinical & Experimental Metastasis·M J Duffy
Jan 2, 1992·International Journal of Cancer. Journal International Du Cancer·T T LahV Turk
Jul 1, 1988·The Biochemical Journal·S Gal, M M Gottesman
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B F SloaneK V Honn
Jun 5, 1981·Science·B F SloaneK V Honn
Oct 1, 1995·British Journal of Cancer·R HildenbrandH J Stutte
Apr 3, 1999·British Journal of Cancer·N IkedaM Miyake
May 18, 1999·Langenbeck's Archives of Surgery·A S Böhle, H Kalthoff
Aug 24, 1999·Cancer Letters·M M Sánchez-MartínA Gómez-Alonso
Sep 23, 2000·Cancer Control : Journal of the Moffitt Cancer Center·D Coppola
Feb 24, 2001·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·M NiedergethmannS Post
Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·P L FernándezA Cardesa
Sep 15, 2004·The European Journal of Surgery = Acta Chirurgica·Mark HartelStefan Post

❮ Previous
Next ❯

Citations

Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stefan EserDieter Saur
Apr 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela M BouttéP Charles Lin
May 10, 2007·Cancer Cell International·Zhen Yang, James L Cox
Jul 23, 2014·BioMed Research International·Sylvester N OsayiPeter Muscarella
May 17, 2014·Experimental & Molecular Medicine·Fabian LohoeferJaroslav Pelisek
Sep 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jan GrimmRalph Weissleder
Aug 21, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·László HerszényiFabio Farinati
Apr 16, 2008·Expert Opinion on Therapeutic Targets·Christine M ArditoHoward C Crawford
Aug 21, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Andrey V ShubinSergey V Kostrov
Nov 7, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Sara SulpizioFederico Selvaggi
Nov 14, 2008·Cancer Letters·Jin-Hyeok HwangYong-Tae Kim
Sep 15, 2015·Biochimica Et Biophysica Acta·Amit WaliaDimitri T Azar
Mar 18, 2009·International Journal of Cancer. Journal International Du Cancer·Shane SullivanJacintha O'Sullivan
Aug 19, 2008·International Journal of Cancer. Journal International Du Cancer·Johannes von BurstinDieter Saur
Apr 19, 2011·Journal of Cellular and Molecular Medicine·Misti SamaiyaShyam S Chauhan
Nov 26, 2015·Nature Reviews. Cancer·Oakley C Olson, Johanna A Joyce
Aug 25, 2015·Pharmacology & Therapeutics·Dhivya R Sudhan, Dietmar W Siemann
Aug 4, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Wilson PetrushnkoAnubhav Mittal
May 31, 2012·World Journal of Gastrointestinal Oncology·Kwang Yeol PaikDong Wook Choi
Jan 19, 2018·Leukemia & Lymphoma·Garima PandeyShyam S Chauhan
Jun 13, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Manuela RogerJuan Antonio Casellas
May 30, 2020·The New England Journal of Medicine·Kohei ShitaraUNKNOWN DESTINY-Gastric01 Investigators
Dec 18, 2014·World Journal of Gastroenterology : WJG·Nidhi SinghAnoop Saraya
Oct 22, 2014·Molecular Medicine Reports·Luosheng ZhangXingwang Gao
Nov 20, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Juan F MartínezJuan Antonio Casellas
Mar 31, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yusuke OgitaniToshinori Agatsuma
Mar 2, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masahiko AokiNarikazu Boku
Feb 26, 2019·Bioorganic Chemistry·Dibyendu DanaSanjai K Pathak
Aug 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xin ZhangXiangyu Ma
Mar 28, 2020·Biochemistry·Zhefu DaiYong Zhang

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