Prognostic impact of HOTAIR expression is restricted to ER-negative breast cancers

Scientific Reports
Yesim Gökmen-PolarSunil Badve

Abstract

Expression of HOX transcript antisense intergenic RNA (HOTAIR), a large intergenic noncoding RNA (lincRNA), has been described as a metastases-associated lincRNA in various cancers including breast, liver and colon cancer cancers. We sought to determine if expression of HOTAIR could be used as a surrogate for assessing nodal metastases and evaluated RNA in situ hybridization (RNA-ISH) assay in a tissue microarray constructed from 133 breast cancer patients. The prognostic value of HOTAIR was further validated in large cohorts using The Cancer Genome Atlas (TCGA) breast cancer subjects. RNA-ISH analysis was successful in 94 cases (17% cases scored 0, 32.9% scored 1, 30.8% scored 2, and 19.1% scored 3). The expression of HOTAIR did not correlate with nodal metastasis regardless of the scoring intensity or with other study parameters (age, tumor size and grade, expression status). Further analysis of TCGA dataset showed that HOTAIR expression was lower in ductal carcinomas but higher in ER-negative tumors. Overexpression of HOTAIR was not associated with nodal metastases or prognosis in ER-positive patients. Its function as a poor prognostic indicator in ER-negative patients was restricted to node-positive patients. HOTAIR appears...Continue Reading

References

Jun 21, 2005·Nature Genetics·Isaac BentwichZvi Bentwich
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Dec 6, 2006·Cancer·Emad A RakhaIan O Ellis
May 15, 2007·Journal of Clinical Pathology·L Da SilvaS R Lakhani
Jul 3, 2007·Cell·Caroline J Woo, Robert E Kingston
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Apr 13, 2010·Brain Research·Irfan A QureshiMark F Mehler
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Nov 30, 2010·Nucleic Acids Research·Paulo P AmaralJohn S Mattick
Jan 5, 2011·Cancer Research·Miao-Chih TsaiHoward Y Chang
May 10, 2011·Trends in Cell Biology·Orly Wapinski, Howard Y Chang
Oct 13, 2011·PloS One·Ewan A GibbWan L Lam
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Sep 8, 2012·Genome Research·Jennifer HarrowTim J Hubbard
Oct 9, 2012·Nucleic Acids Research·Pieter-Jan VoldersPieter Mestdagh
May 15, 2013·Journal of Hematology & Oncology·Yan ZhuangBin Shan
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Nov 22, 2013·Breast Cancer Research and Treatment·Kristina P SørensenTorben A Kruse
Feb 19, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Arunoday BhanSubhrangsu S Mandal
Jun 14, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xiao-Han ShenXiang Du

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Citations

Dec 15, 2015·Ageing Research Reviews·Sukhleen Kour, Pramod C Rath
Jan 23, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Leah QuinnSteven G Gray
Nov 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei Song, Shu-Bing Zou
Jan 10, 2017·Journal of Cellular Physiology·Monica CantileGerardo Botti
Feb 23, 2018·International Journal of Molecular Sciences·Elżbieta PawłowskaJanusz Blasiak
Dec 7, 2017·Frontiers in Genetics·Niloofar AvazpourMaryam Tahmasebi Birgani
Aug 23, 2018·Journal of Cellular Physiology·Gerardo BottiMonica Cantile
Sep 13, 2016·Science Advances·Olivier Van GrembergenFrançois Fuks
Jan 8, 2019·Clinical Genetics·Carolina MathiasJaqueline C de Oliveira
Dec 13, 2017·The Biochemical Journal·Antara BiswasKartiki V Desai
Apr 10, 2019·International Journal of Cancer. Journal International Du Cancer·Liang-Chih LiuShao-Chun Wang
Aug 10, 2017·Oncology Letters·Kaijiong ZhangJinbo Liu
Sep 5, 2019·Cells·Yujing ChiJichun Yang
Mar 5, 2016·Oncotarget·Hairong LiuYin-Yuan Mo
Jun 25, 2016·Oncotarget·Ronan FlippotDavid Khayat
Sep 14, 2018·International Journal of Molecular Sciences·Alma D Campos-ParraCarlos Pérez-Plasencia
Jan 29, 2019·Frontiers in Endocrinology·Rainer GirgertCarsten Gründker
May 14, 2020·Cancers·Monica CantileGerardo Botti
Jan 7, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Taruna RajagopalNageswara Rao Dunna
Dec 7, 2021·Frontiers in Oncology·Martin C AbbaC Marcelo Aldaz

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Methods Mentioned

BETA
biopsy
Assay

Software Mentioned

Statistical Package for Social Sciences
R ( R Foundation for Statistical Computing
SPSS

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