Prognostic impact of nestin expression in resected large cell neuroendocrine carcinoma of the lung

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Shinichiro RyugeNoriyuki Masuda

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the lung is categorized as a high-grade neuroendocrine carcinoma with an aggressive clinical behavior. Nestin is a class VI intermediate filament protein expressed in stem/progenitor cells during central nervous system development. Recently, we reported that nestin expression is a prognostic indicator of a poorer survival probability in patients with resected NSCLC. In the present study, we aimed to determine its prognostic significance concerning survival in patients with resected LCNEC. Nestin expression in tumor cells was immunohistochemically studied in 30 patients with resected LCNEC, and its associations with clinicopathologic parameters including the Ki-67 labeling index (LI) and TTF-1 expression were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of nestin expression on survival. Nestin expression was observed in 8 of the 30 (26.7%) LCNECs. Clinicopathologically, although no significant association between nestin expression and age, gender, smoking habits, p-TNM stage, tumor size, nodal status, or TTF-1 expression was observed, nestin expression was significantly associated with a high Ki-67 LI (P=0.012). On su...Continue Reading

References

Jan 1, 1997·The Annals of Thoracic Surgery·C M DreslerM R Wick
Aug 31, 2002·Science·David M BermanPhilip A Beachy
Jul 2, 2003·Molecular and Cellular Biology·Cecilia M SahlgrenJohn E Eriksson
Apr 6, 2004·The Annals of Thoracic Surgery·Massimiliano PaciGiorgio Sgarbi
Sep 14, 2004·Nature·Sunil S KarhadkarPhilip A Beachy
Nov 19, 2004·Nature·Philip A BeachyDavid M Berman
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hisao AsamuraKanji Nagai
May 16, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giulia VeronesiLorenzo Spaggiari
Oct 26, 2006·The Annals of Thoracic Surgery·Akira IyodaTakehiko Fujisawa
Dec 23, 2006·Seminars in Thoracic and Cardiovascular Surgery·Felix G Fernandez, Richard J Battafarano
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN Participating Institutions
Dec 24, 2009·Cancer Science·Caigang LiuPing Lu
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jitsuo UsudaNorihiko Ikeda

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Citations

Sep 10, 2013·Journal of Cancer Research and Clinical Oncology·Akiko TakahashiAtsushi Ochiai
Jan 20, 2015·Expert Review of Molecular Diagnostics·Cecilia LindskogPatrick Micke
Feb 9, 2013·Seminars in Oncology·Emily K Bergsland
Jan 15, 2019·Nuclear Medicine Communications·Barbara BromińskaMarek Ruchała
Nov 1, 2017·The Journal of Pathology. Clinical Research·Maria RamnefjellLars A Akslen
Mar 6, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Wesam M OsmanNaglaa S Ahmed

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