Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients

Annals of Surgical Oncology
Shinkichi TakamoriYoshihiko Maehara

Abstract

Programmed death-ligand 1 (PD-L1) expression on lung cancer cells is a prognostic marker and a predictive biomarker for response to immunotherapy. However, previous clinical trials have suggested that other programmed cell death 1 ligands, including programmed death-ligand 2 (PD-L2), might have clinical impacts. This study aimed to analyze the prognostic significance of PD-L2 expression in lung adenocarcinoma patients. The study included 433 patients who underwent surgical resection for lung adenocarcinoma between 2003 and 2012 at Kyushu University Hospital. Both PD-L1 and PD-L2 expression were evaluated by immunohistochemistry. The cutoff value for PD-L2 positivity was set at 1% according to a time-dependent receiver operating characteristic curve for 5-year survival. Of the 433 patients, 306 (70.7%) were positive for PD-L2. No significant association between PD-L1 and PD-L2 expression was observed (P = 0.094). The multivariate analysis showed that the independent predictors of PD-L2 positivity were never-smoker status (P = 0.002), poor differentiation grade (P = 0.008), and advanced stage (P = 0.048). The PD-L2-positive patients had significantly shorter disease-free survival (DFS) (P = 0.018) and overall survival (OS) (P = 0...Continue Reading

References

Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·P'ng Loke, James P Allison
Oct 28, 2003·European Journal of Immunology·Nancy RodigGordon J Freeman
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KonishiMasaharu Nishimura
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Aug 4, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·David S EttingerUNKNOWN NCCN Non-Small Cell Lung Cancer Panel Members
May 23, 2012·Clinical & Developmental Immunology·Esdy N RozaliW Joost Lesterhuis
Feb 13, 2013·The Journal of Thoracic and Cardiovascular Surgery·Hisao AsamuraUNKNOWN Japan Clinical Oncology Group Lung Cancer Surgical Study Group
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 11, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Moon-Young KimDoo Hyun Chung
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Jul 18, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jaemoon KohDoo Hyun Chung
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 17, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Antonio CallesPasi A Jänne
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kazuki TakadaYoshihiko Maehara
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Dec 4, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fred R HirschKeith M Kerr
Mar 30, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daisuke ShibaharaIsamu Okamoto

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Citations

Jan 12, 2021·Frontiers in Immunology·Jossie RotmanEkaterina S Jordanova
Dec 29, 2020·International Immunopharmacology·Xiaochun LinCongqin Xiao
Feb 27, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S MiwaH Tsuchiya
Jun 29, 2021·Frontiers in Oncology·Qianhui GuSong He

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