Prognostic impact of Skp2 and p27 in human breast cancer

Breast Cancer Research and Treatment
Frank TraubReinhard von Wasielewski

Abstract

The cell cycle is controlled by cyclin-dependent kinases and one of the key players is the cyclin-dependent kinase inhibitor p27. The F-box protein Skp2 is a regulator of G1-S transition and promotes specifically the ubiquitin-mediated proteolysis of p27 via the proteasome pathway. In breast carcinomas, overexpression of Skp2 has been implicated in cell transformation and oncogenesis, but no data are available on the association of Skp2 and p27. The purpose was to evaluate the prevalence of Skp2 and p27 expression and determine whether a combined index has prognostic power in breast carcinomas. Three hundred and thirty-eight breast cancer specimens were analyzed for Skp2 and p27 expression by immunohistochemistry. Results were compared with classical histopathological criteria as well as other prognostic markers (ER, PR, HER2, p53, Ki-67) and correlated with the clinical outcome. Thirty-four percent of breast cancers analyzed showed both a high expression for Skp2 and a low expression for p27. In univariate Kaplan-Meier analysis, this combination was found to be significantly associated with a worse clinical course (p<0.0001). Including staging, grading and the other tested marker, the Skp2/p27 index proved to be of prognostic ...Continue Reading

References

Feb 23, 1999·The American Journal of Pathology·R V LloydB W Scheithauer
Mar 5, 1999·Breast Cancer Research and Treatment·I C Henderson, A J Patek
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·M BarbareschiR Michalides
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S CariouJ M Slingerland
Mar 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C BastUNKNOWN American Society of Clinical Oncology Tumor Markers Expert Panel
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·A NocitoG Sauter
Nov 15, 2002·The New England Journal of Medicine·Khandan KeyomarsiSarah S Bacus
Jan 1, 2003·Seminars in Cancer Biology·Joanna Bloom, Michele Pagano
Jun 27, 2003·The New England Journal of Medicine·Beverly S Mitchell
Jul 24, 2003·The Surgical Clinics of North America·S Eva SingletaryFrederick L Greene
Sep 11, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Michael MengelReinhard von Wasielewski
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carlos L Arteaga
May 13, 2004·The Journal of Biological Chemistry·Lynn M KnowlesJeffrey W Smith
Nov 3, 2004·Genes & Development·Uta KossatzNisar P Malek
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Jun 3, 2005·Cancer Cell International·Mario BoccadoroJamie Cavenagh

❮ Previous
Next ❯

Citations

Jun 4, 2011·Journal of Gastrointestinal Cancer·Jaudah Al-MaghrabiMohmmad Al-Qahtani
May 25, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer R WonTorsten O Nielsen
May 27, 2008·Nature Reviews. Cancer·David Frescas, Michele Pagano
Jan 16, 2010·The Journal of Biological Chemistry·Da-Jung JungWang-Jae Lee
Jan 18, 2013·Briefings in Functional Genomics·Vincenzo Di Cerbo, Robert Schneider
Dec 6, 2008·Genes & Development·Gustavo A Miranda-CarboniTimothy F Lane
Oct 5, 2010·Pigment Cell & Melanoma Research·Amy E RoseIman Osman
Nov 17, 2007·The Journal of Clinical Investigation·Tao ZuoYang Liu
Aug 14, 2013·International Journal of Molecular Sciences·Hongge ChengShengming Dai
Oct 10, 2006·Breast Cancer Research and Treatment·Jessica GawendaReinhard von Wasielewski
May 9, 2015·International Journal of Oncology·Jian GongJi-Rong Huo
Dec 23, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jianfei Qi, Ze'ev A Ronai
Jun 3, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Mo Xiang-LanLin Han-Liang
Feb 25, 2009·Journal of Surgical Oncology·Anjita PandeyHari S Shukla
Jan 21, 2014·Journal of Cellular Physiology·Katerina D Fagan-SolisKathleen F Arcaro
Mar 21, 2009·Journal of Cellular and Molecular Medicine·Xiaoxiang GuanMacus Tien Kuo
Jun 19, 2012·European Journal of Pharmacology·Shih-Han SunJen-Kun Lin
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian LuoHongzhen Lan
Jul 10, 2012·Cell·Hiroyuki InuzukaWenyi Wei
Oct 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin SuXueyun Huo
Jan 18, 2017·The Journal of Pathology·Panimaya Jeffreena MirandaYgal Haupt
Aug 27, 2015·Breast Cancer : Basic and Clinical Research·Chengcheng YangHui Guo
Dec 28, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Juan ZhouSan-Gang Wu
Mar 5, 2015·The EMBO Journal·Linxiang LanWalter Birchmeier
Jan 20, 2016·International Journal of Oncology·Jian GongJi-Rong Huo
Sep 3, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin FilipitsUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Dec 5, 2020·Drug Discovery Today·Xin-Yu TongHong-Yu Zhang

❮ Previous
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