Prognostic Impact of the Number of Examined Lymph Nodes in Stage II Colorectal Adenocarcinoma: A Retrospective Study

Gastroenterology Research and Practice
Purun LeiJuekun Wu

Abstract

Evaluation of lymph node status is critical in colorectal carcinoma (CRC) treatment. However, as patients with node involvement may be incorrectly classified into earlier stages if the examined lymph node (ELN) number is too small and escape adjuvant therapy, especially for stage II CRC. The aims of this study were to assess the impact of the ELN on the survival of patients with stage II colorectal cancer and to determine the optimal number. Data from the US Surveillance, Epidemiology, and End Results (SEER) database on stage II resected CRC (1988-2013) were extracted for mathematical modeling as ELN was available since 1988. Relationship between ELN count and stage migration and disease-specific survival was analyzed by using multivariable models. The series of the mean positive LNs, odds ratios (ORs), and hazard ratios (HRs) were fitted with a LOWESS (Locally Weighted Scatterplot Smoothing) smoother, and the structural break points were determined by the Chow test. An independent cohort of cases from 2014 was retrieved for validation in 5-year disease-specific survival (DSS). An increased ELN count was associated with a higher possibility of metastasis LN detection (OR 1.010, CI 1.009-1.011, p < 0.001) and better DSS in LN ne...Continue Reading

References

Nov 1, 1989·The British Journal of Surgery·K W Scott, R H Grace
Apr 1, 1994·Diseases of the Colon and Rectum·F HernanzM Gómez-Fleitas
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·R V IyerM Torosian
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E TepperR J Mayer
Jan 7, 2003·Annals of Surgical Oncology·Richard S SwansonKirby I Bland
May 1, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hsiang-Lin TsaiJaw-Yuan Wang
Jul 12, 2008·Journal of Surgical Oncology·Claudio Almeida QuadrosFernanda Fahel
Oct 22, 2014·ANZ Journal of Surgery·Jianpei LiuHongbo Wei
Nov 18, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Masashi YahagiYuko Kitagawa
May 11, 2016·Scandinavian Journal of Gastroenterology·Stig NordervalSonja E Steigen
Oct 4, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Giovanni Li DestriStefano Puleo
Apr 5, 2018·Annals of Surgical Oncology·Martin R Weiser
May 26, 2018·Current Treatment Options in Oncology·Michele GhidiniGianluca Tomasello
Aug 11, 2018·PloS One·Philipp SchrembsBruno Märkl
Oct 3, 2018·Annals of Surgical Oncology·Eiji ShintoKenichi Sugihara

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Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

SEER∗Stat
SAS
LOWESS
SPSS
R

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