Prognostic impact of thoracic duct lymph node metastasis in esophageal squamous cell carcinoma.

Annals of Gastroenterological Surgery
Satoru MatsudaYuko Kitagawa

Abstract

We have previously reported the existence of lymph nodes surrounding the thoracic duct ( TDLN) and transthoracic esophagectomy (TTE) with thoracic duct (TD) resection increased the number of lymph nodes (LNs) retrieved. The current study aims to evaluate the prognostic impact of TDLN metastasis in esophageal cancer patients subdivided by its location and comparing the patients' survival with those with extra-regional LN metastasis. Patients who underwent TTE with TD resection for esophageal squamous cell carcinoma (ESCC) were reviewed. Patients were classified into those with or without TDLN metastasis, and clinicopathological factors were compared between groups. TDLN was further divided into TDLN-Ut/Mt/Lt based on the location in the mediastinum. The relapse-free survival (RFS) and overall survival (OS) were compared between groups. Of 232 patients, TDLN metastasis was observed in 17 (7%). RFS and OS were significantly worse in the TDLN metastasis group. TDLN metastasis was shown to be an independent prognostic factor for RFS and OS in the multivariate analysis. The negative prognostic impact of TDLN metastasis was evident in TDLN-Mt/Lt. The RFS and OS of patients with TDLN metastasis were almost identical to those with posit...Continue Reading

References

Sep 13, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H Udagawa, H Akiyama
Aug 2, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Satoshi AikoTadaaki Maehara
Aug 21, 2007·Japanese Journal of Clinical Oncology·Bach ArdalanParvin Ganjei-Azar
Apr 24, 2009·Annals of Surgery·Hiroya TakeuchiYuko Kitagawa
Aug 20, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yang ZhaoXi Jing Wang
Oct 21, 2016·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Satoru MatsudaYuko Kitagawa
Jan 24, 2017·Esophagus : Official Journal of the Japan Esophageal Society·UNKNOWN Japan Esophageal Society
Jan 24, 2017·Esophagus : Official Journal of the Japan Esophageal Society·UNKNOWN Japan Esophageal Society
Apr 28, 2017·Annals of Cardiothoracic Surgery·Thomas W RiceEugene H Blackstone
Aug 18, 2017·Journal of Thoracic Disease·Satoru MatsudaYuko Kitagawa
Mar 28, 2018·The Annals of Thoracic Surgery·Bernadette SchurinkRichard van Hillegersberg

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