Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure - A Multicenter Prospective Cohort Study

Circulation Journal : Official Journal of the Japanese Circulation Society
Soichiro TadakiHiroaki Shimokawa

Abstract

Metabolic syndrome (MetS) is involved in the increased risk of atherosclerotic cardiovascular diseases. We have previously reported that the prevalence of MetS is more than 2-fold greater in patients with chronic heart failure (CHF) than in the general population in Japan. However, the prognostic impact of MetS in CHF patients remains to be elucidated. In the present nationwide, large-scale clinical study in Japan, we enrolled 4,762 patients with Stage C/D CHF. The prevalence of MetS by the definition of the Japanese Committee for the Diagnostic Criteria in 2005 was 41.3% (50.6% in males, 21.5% in females). MetS was characterized by higher prevalence of males, obesity and lifestyle-related comorbidities, including glucose intolerance, dyslipidemia and hypertension. Multivariate Cox hazard analysis showed that MetS was associated with increased incidence of the composite of all-cause death and atherosclerotic events in males (hazard ratio [HR] 1.28; 95% confidence interval [CI] 1.06-1.54, P=0.011) but not in females (HR 1.23, 95% CI 0.87-1.75, P=0.241). Among the components of MetS, over waist circumference and glucose intolerance were significantly associated with increased incidence of the composite endpoint (HR 1.23, P=0.038,...Continue Reading

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Citations

Jan 30, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Susumu Adachi
Jan 6, 2018·The Journal of Cardiovascular Nursing·Lee Anne SiegmundShannon L Morrison
Apr 30, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro Seo, Kazutaka Aonuma
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Zhuo-Ming HuangZhuo-Wen Huang

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