Prognostic implications of advancing nodal stage in anal cancer: evaluating AJCC 8 staging changes through an NCDB analysis.

International Journal of Colorectal Disease
Eli D ScherJordan R Kharofa

Abstract

In the AJCC8, nodal staging for squamous cell carcinoma of the anus (SCCA) has been changed to a binary format (N0 or N+), and overall stage groups have been redefined. We evaluated the effect of AJCC8 nodal stage by T stage and hypothesized similar survival regardless of the extent of AJCC7-defined nodal involvement. The National Cancer Database (NCDB) was used to identify patients' SCCA. Overall survival (OS) for each T stage within the AJCC7 was compared with increasing nodal stage, as well as for the new AJCC8 overall stage groups and subsets. There were 6738 patients analyzed. The 5-year OS by AJCC8 stage was I = 81%, IIA = 78%, IIB = 64%, IIIA = 69%, IIIB = 59%, IIIC = 57% (p < 0.0001). In AJCC8 IIIA (T1-2, N+), there was no difference in 5-year OS between T1N+ or T2N+ patients (70.3% vs 68.6%, p = 0.09). A significant survival difference was demonstrated between AJCC7 N1, N2, and N3 for patients with either T1 (p = 0.0047) or T2 (p = 0.0389) disease. In the AJCC 8 IIIC (T3-4, N+) group, there was no difference in 5-year OS between T3N+ and T4N+ (58% vs 55%, p = 0.81). There was no OS difference between AJCC7 N1-3 for either T3 (p = 0.19) or T4 (0.35) disease. For earlier T stages, advancing nodal stage per AJCC7 retains ...Continue Reading

References

Feb 1, 1985·The American Journal of Medicine·L LeichmanC Leichman
Sep 1, 1993·International Journal of Radiation Oncology, Biology, Physics·A AllalR Egeli
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 24, 2008·JAMA : the Journal of the American Medical Association·Jaffer A AjaniChristopher Willett
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesUNKNOWN ESMO Guidelines Working Group
Sep 27, 2012·Cancer·Robert Glynne-JonesUNKNOWN United Kingdom Coordinating Committee on Cancer Research Anal Cancer Trial Working Party
Nov 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonChristopher G Willett
Sep 17, 2013·International Journal of Radiation Oncology, Biology, Physics·Leonard L GundersonChristopher G Willett
Feb 24, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ivona BaricevicAndrew G Renehan
Jul 16, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·I ParwaizD E Messenger

❮ Previous
Next ❯

Citations

Apr 22, 2021·Current Opinion in Oncology·Emilio Francesco GiuntaFrancesco Sclafani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2021 Meta ULC. All rights reserved