PMID: 2495516Feb 1, 1989Paper

Prognostic implications of nuclear DNA content in head and neck cancer

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Y C GuoG V Osetinsky

Abstract

The nuclear DNA content was measured in formalin-fixed and deparaffined specimens of 296 oral, pharyngeal, and laryngeal squamous cell carcinomas from patients in whom the clinical outcome was known. One hundred ninety (64%) contained cells with abnormal DNA (DNA aneuploid or tetra/polypoid). Only 32% (60 of 190) of the patients with DNA nondiploid cancers survived 5 years, compared with 49% (52 of 106) of the patients with DNA diploid cancers. When the findings were controlled for clinical stage, patients whose tumors were DNA diploid had a survival advantage at each stage. Histologic grading showed less correlation, because only patients with well-differentiated carcinomas had a survival advantage if their tumors were DNA diploid. These data showed that determination of DNA content in cancers of the head and neck can offer prognostic information not provided by other means and enhance the diagnosis of cancer.

References

Apr 1, 1987·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M M GoldsmithH C Pillsbury
May 1, 1986·Pathology, Research and Practice·G FranzénB Nordenskjöld
Nov 1, 1986·Archives of Otolaryngology--head & Neck Surgery·A S KaplanJ S Coon
Oct 1, 1986·American Journal of Surgery·M M GoldsmithH C Pillsbury
Feb 1, 1974·The Journal of Cell Biology·P N Dean, J H Jett
Oct 1, 1984·Cancer Genetics and Cytogenetics·W HiddemannA A Sandberg
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D W HedleyE A Musgrove

❮ Previous
Next ❯

Citations

Sep 25, 2001·The Laryngoscope·J P RodrigoJ A Martínez
Apr 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K NylanderG Roos
Aug 1, 1994·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·K SuzukiT Nakajima
Apr 29, 2004·Clinical Otolaryngology and Allied Sciences·P A NixN Stafford
Oct 1, 1990·American Journal of Surgery·B H CampbellR G Hoffmann
Oct 1, 1992·European Journal of Cancer. Part B, Oral Oncology·E Munck-WiklandG Auer
May 22, 2001·Head & Neck·H StruikmansI van der Tweel
Apr 1, 1993·Clinical Otolaryngology and Allied Sciences·H A WesterbeekA J Balm
Sep 1, 1995·The Annals of Otology, Rhinology, and Laryngology·J M ResnickW Jaszcz
Jul 1, 1991·The Annals of Otology, Rhinology, and Laryngology·M A WalterS C Peiper
Dec 1, 1989·The Journal of Laryngology and Otology·A el-NaggarM E Tortoledo
Apr 10, 2004·Acta Oto-laryngologica·K PekkolaR Grenman
Mar 31, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mohammed Iqbal SyedLouise J Clark
Oct 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·E N MyersJ R de los Toyos
Oct 1, 1991·Clinical Otolaryngology and Allied Sciences·P M Stell
Jan 1, 1997·The Journal of Laryngology and Otology·S K SarkerD V Coleman
Mar 1, 1996·The Journal of Laryngology and Otology·S K SarkerD V Coleman
Jul 1, 1995·Head & Neck·M TytorB Nordenskjöld
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·P GemrydB Nordenskjöld
Sep 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J P RodrigoC Suárez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.