Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas

International Journal of Immunopathology and Pharmacology
E MaioranoG Viale

Abstract

The gene numb encodes for a protein (Numb) involved in cell fate decisions in Drosophila, with proposed endocytic and developmental functions in mammalians. The distribution pattern of Numb in human tissues however, has not been fully characterized. We set out to explore the immunohistochemical expression of Numb in normal and neoplastic (28 adenoid cystic and 34 mucoepidermoid carcinomas) salivary glands, and correlated the results with the clinico-pathologic features of the neoplasms. Intense Numb immunoreactivity was detected in normal ductal cells and in a subset of acinar cells. In salivary carcinomas, we detected diffuse and intense Numb immunostaining in 5 adenoid cystic and 8 mucoepidermoid carcinomas. By contrast, the majority of adenoid cystic and mucoepidermoid cancers showed only moderate (14 and 5 cases) or focal staining (9 and 21 cases), respectively. The corresponding expression of Numb mRNA was documented in normal parotid gland and adenoid cystic carcinoma. Numb immunoreactivity was inversely correlated with the histological grade and Ki-67 immunoreactivity of both adenoid cystic and mucoepidermoid carcinomas. In addition, while tumor grade, stage, Ki-67 and Numb immunoreactivity were associated with disease-f...Continue Reading

References

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Citations

Dec 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin SimaYanxin Mao
Aug 20, 2014·Nature Reviews. Urology·Angela N FloresLaure Marignol
Mar 7, 2018·Oncotarget·José Manuel García-Heredia, Amancio Carnero
May 20, 2014·Familial Cancer·Ayelet ShaiSteven A Narod
Jul 15, 2015·International Journal of Molecular Medicine·Chengzhi XieXundi Xu
Mar 15, 2015·Frontiers in Oncology·Salvatore CorallinoGiorgio Scita
Jul 29, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yanjing GuoWei-Qiang Gao
Feb 6, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jose Manuel Garcia-HerediaAmancio Carnero
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hong PengZiwei Wang
Sep 24, 2011·Experimental Cell Research·Philipp EuskirchenHrvoje Miletic
Feb 11, 2015·Journal of Cell Science·Nicola De FranceschiJohanna Ivaska
Jun 16, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A Ostrakhovitch
Oct 14, 2010·Biochimica Et Biophysica Acta·Salvatore PecePier Paolo Di Fiore

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