Prognostic implications of renal dysfunction in patients hospitalized with heart failure: data from the last decade of clinical investigations.

Heart Failure Reviews
Filippo BrandimarteMihai Gheorghiade

Abstract

Numerous studies over the last decade have demonstrated that renal dysfunction and worsening renal function (WRF) are common in patients hospitalized for heart failure (HHF) and appear to be associated with poor in-hospital and post-discharge outcomes. Unfortunately, its etiology has not been completely understood, and its prediction during hospitalization remains challenging. The evaluation of renal impairment during hospitalization should take into consideration the underlying renal substrate (e.g., predisposing clinical comorbidities such as diabetes and hypertension), initiating mechanisms (e.g., in-hospital therapies such as diuretics), and amplifying factors (neurohormonal and hemodynamic profile changes). Various patterns of WRF may have different prognostic implications and may require different therapeutic approaches. WRF may be initially classified by duration (transient vs. persistent) and by etiology (elevated venous pressures vs. arterial underfilling). Other critical contributing factors during hospitalization include progressive left ventricular dysfunction, neurohormonal activation, and medications. Transient WRF as a result of aggressive therapy targeting congestion may not be associated with poor outcomes. Per...Continue Reading

References

Sep 17, 1998·The New England Journal of Medicine·R G Luke
Dec 18, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C A JonesL Y Agodoa
Jul 26, 2002·Journal of Cardiac Failure·Stephen S GottliebHarlan M Krumholz
May 14, 2003·Hypertension·Peeter KööbiIlkka Pörsti
Sep 16, 2003·The American Journal of Cardiology·Claudia U ChaeGary C Curhan
Jan 13, 2004·Journal of the American College of Cardiology·Daniel E FormanHarlan M Krumholz
Jul 13, 2004·The American Journal of Cardiology·Tom D J SmildeDirk J Van Veldhuisen
Oct 19, 2004·Journal of the American College of Cardiology·Justin EzekowitzUNKNOWN APPROACH Investigators
Jul 13, 2006·Archives of Internal Medicine·Kirsten Bibbins-DomingoMichael G Shlipak
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Mihai GheorghiadeUNKNOWN OPTIMIZE-HF Investigators and Coordinators
Jan 30, 2007·American Journal of Nephrology·Harini ChittineniSteven Fishbane
Aug 7, 2007·Journal of Cardiac Failure·J Thomas HeywoodUNKNOWN ADHERE Scientific Advisory Committee and Investigators
Oct 2, 2007·Journal of Cardiovascular Medicine·Mario PetrettaDomenico Bonaduce
Oct 25, 2007·Nephron. Clinical Practice·Rovshan M IsmailovFrederick A Spencer
Mar 29, 2008·Journal of the American College of Cardiology·Anju NohriaJames A Hill
Nov 15, 2008·Journal of the American College of Cardiology·Claudio RoncoRinaldo Bellomo
Feb 3, 2009·American Heart Journal·Grigorios GiamouzisJaved Butler
Feb 14, 2009·Journal of the American College of Cardiology·Wilfried MullensW H Wilson Tang
Jan 20, 2010·European Journal of Heart Failure·Amalia Vaz PérezMathias Rauchhaus
Feb 27, 2010·Journal of Cardiovascular Medicine·Filippo BrandimarteMihai Gheorghiade
Jun 12, 2010·The American Journal of Cardiology·Robb D KociolAdrian F Hernandez
Dec 15, 2010·The American Journal of Cardiology·David E LanfearL Keoki Williams
Mar 4, 2011·The New England Journal of Medicine·G Michael FelkerUNKNOWN NHLBI Heart Failure Clinical Research Network
Jul 26, 2011·European Heart Journal·Piero Ruggenenti, Giuseppe Remuzzi

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Citations

May 28, 2013·Heart Failure Reviews·Daniela SchmitterAdriaan A Voors
May 24, 2013·Current Cardiology Reports·Dmitry ShchekochikhinJoAnn Lindenfeld
Jul 23, 2013·Current Heart Failure Reports·Kalkidan Bishu, Margaret M Redfield
May 15, 2013·Journal of Cardiac Failure·Muthiah Vaduganathan, Mihai Gheorghiade
Sep 23, 2014·Journal of cardiology·Muthiah Vaduganathan, Mihai Gheorghiade
Nov 22, 2013·European Journal of Heart Failure·Sven MeyerAdriaan A Voors
Jul 6, 2014·European Journal of Internal Medicine·Rodrigo PimentelAna Azevedo
Jun 18, 2014·The American Journal of Medicine·Muthiah VaduganathanMihai Gheorghiade
Jun 28, 2016·Current Medical Research and Opinion·Jason P SwindleAylin Altan
May 23, 2014·Circulation. Heart Failure·Steven R GoldsmithJohn Burnett
Nov 9, 2018·PloS One·Malik BenmachicheMarie Méan
Jul 24, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Beytullah ÇakalBilal Boztosun

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