PMID: 8402455Oct 15, 1993Paper

Prognostic importance of histologic vascular density in cervical cancer treated with hypertensive intraarterial chemotherapy

Cancer
Y KohnoM Kitao

Abstract

Over the past 20 years, various methods have been suggested to determine the histopathologic stage and grade of cervical cancer for predicting biologic behavior during chemotherapy. However, none of these complicated techniques have proved consistently accurate enough to predict chemotherapeutic effects on locally advanced cervical cancer. Primary treatment with hypertensive intraarterial chemotherapy and, 4 weeks later, with radical hysterectomy were performed on 20 patients with locally advanced cancer of the uterine cervix (International Federation of Gynecology and Obstetrics [FIGO] Stages IIa-IVa). The vascular densities of biopsy specimens from pretreatment cancers stained by the Elastica-Goldner technique were measured semiquantitatively. Cytologic and histologic changes in the early stages after the intraarterial chemotherapy were simultaneously recorded. Patients were divided into two groups after analysis of the final histologic effects on operation materials in accordance with the criteria of the Japan Society for Cancer Therapy: (1) an effective group (> or = Grade 2; n = 7) or (2) a noneffective group (< Grade 2; n = 13). The vascular densities of the effective and noneffective groups were 6.91 plus or minus 4.51/m...Continue Reading

Citations

Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Weidner
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J KodamaT Kudo
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D Cantu De LeónJ De La Garza Salazar
Aug 7, 2001·Cancer Investigation·J K Wolf, P T Ramirez
Aug 30, 2008·Surgical Oncology Clinics of North America·Takeshi MaruoYonson Ku
Feb 22, 2005·Biochemical and Biophysical Research Communications·Uwe A WittelSurinder K Batra

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