Prognostic importance of the extent of ulceration in patients with clinically localized cutaneous melanoma

Annals of Surgery
Florentien E M In 't HoutRichard A Scolyer

Abstract

To determine the prognostic value of the extent of ulceration, categorized as diameter of ulceration and as percentage of invasive melanoma diameter. Ulceration is an adverse prognostic factor for clinically localized primary cutaneous melanoma. However, the prognostic significance of the extent of ulceration remains unclear. Clinicopathologic and follow-up data on 4661 patients treated at a single center were analyzed. Both the presence and extent of ulceration were independent predictors of survival. The 5-year melanoma-specific survival (MSS) for ulcerated and nonulcerated melanomas was 77.6% and 91.3%, respectively. The 5-year MSS for minimally/moderately ulcerated melanomas (≤70% or ≤5 mm) was 80.4% and 82.7%, respectively, compared to extensively ulcerated melanomas (>70% or >5 mm), which had a 5-year MSS of 66.4% and 59.3%. On multivariate analysis, tumor thickness and the presence/absence of mitoses were the most powerful predictors of MSS. The presence of ulceration was also an independent predictor of poorer MSS (hazard ratio [HR] = 1.55, P < 0.001). Patients with minimally/moderately ulcerated tumors (≤70% or ≤5 mm) had a significantly higher risk of death (HR = 1.53 and HR = 1.39, respectively) compared to nonulcera...Continue Reading

References

Jan 1, 1984·The Journal of Dermatologic Surgery and Oncology·C L DayT J Harrist
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Aug 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A SpatzR L Barnhill
Dec 6, 2003·The American Journal of Surgical Pathology·Richard A ScolyerJonathan R Stretch
Apr 6, 2006·Journal of the National Cancer Institute·Véronique WinnepenninckxUNKNOWN Melanoma Group of the European Organization for Research and Treatment of Cancer
Oct 26, 2006·The American Journal of Surgical Pathology·Hege Grande SarpaMohammed Kashani-Sabet
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruce ElliottUNKNOWN European Organization for Research and Treatment of Cancer Melanoma Group
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H GogasR Dummer
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak

❮ Previous
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Citations

Sep 26, 2013·The American Journal of Surgical Pathology·Richard A ScolyerUNKNOWN International Collaboration on Cancer Reporting
Feb 27, 2014·Nature Communications·Barbara HeidenreichRajiv Kumar
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Mario Mandalà, Daniela Massi
Apr 8, 2016·Annals of Surgical Oncology·Alyson L MaharPatti A Groome
Aug 24, 2017·Plastic and Reconstructive Surgery. Global Open·Pieter G L KoolenSamuel J Lin
Dec 15, 2017·The American Journal of Surgical Pathology·Tristan J DoddsRichard A Scolyer
Oct 14, 2017·CA: a Cancer Journal for Clinicians·Jeffrey E GershenwaldUNKNOWN for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Disc
Nov 13, 2014·American Journal of Clinical Pathology·Marie L Bønnelykke-BehrndtzTorben Steiniche
Jun 21, 2018·Expert Review of Anticancer Therapy·Emily Z Keung, Jeffrey E Gershenwald
May 23, 2012·Nature Reviews. Clinical Oncology·M Teresa Villanueva
Feb 16, 2020·Journal of the National Cancer Institute·Emily Z Keung, Jeffrey E Gershenwald
Dec 6, 2019·Current Medicinal Chemistry·Martina StrudelPaolo A Ascierto
Jul 31, 2020·The British Journal of Dermatology·M J Wilkinson, D E Gyorki
Jul 22, 2018·Scientific Reports·Sivaramakrishna RachakondaRajiv Kumar
Nov 24, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Richard A ScolyerVictor G Prieto
May 4, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M FábiánS Kárpáti
Jan 19, 2021·Revista española de patología : publicación oficial de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Citología·Antonio Tejera-VaquerizoJosé Luis Rodríguez-Peralto
Dec 27, 2019·The Journal of Investigative Dermatology·Basia M MichalskiEva A Hurst

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