Prognostic importance of thymidylate synthase expression in early breast cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
B C PestalozziPatrick Johnston

Abstract

To assess the prognostic importance of thymidylate synthase (TS) expression in breast tumors of patients with early-stage breast cancer, and to determine whether the benefit of chemotherapy (CT) is associated with TS expression. The level of TS expression was evaluated in 210 node-negative and 278 node-positive patients enrolled onto Trial V of the International Breast Cancer Study Group ([IBCSG] formerly the Ludwig Breast Cancer Study Group) with a median follow-up time of 8.5 years. TS expression was assessed using the immunohistochemical method with the monoclonal antibody TS 106 on paraffin-embedded tissue specimens. High TS expression was associated with a significantly worse prognosis in node-positive but not in node-negative breast cancer patients. Twenty-seven percent of node-positive patients with high TS expression were disease-free at 10 years, compared with 44% of node-positive patients with low TS expression (P = .03). Forty-one percent of patients with node-positive high-TS-expressing tumors were alive after 10 years, compared with 49% of those with low TS expression (P = .06). The association between TS and disease-free survival (DFS) and overall survival (OS) was independent of other prognostic factors such as t...Continue Reading

Citations

Nov 24, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A S HaqqaniH C Birnboim
Aug 8, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Takeo NomuraYoshio Nomura
May 31, 2008·Cancer Metastasis Reviews·Sridhar Nimmagadda, Anthony F Shields
Dec 19, 2013·International Journal of Cancer. Journal International Du Cancer·Hye Seung LeeMaria Zajac-Kaye
Apr 14, 2016·Proteomics. Clinical Applications·Prachi GuptaYogeshwer Shukla
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Yasushi SagaKeiya Ozawa
May 5, 2005·Journal of the National Cancer Institute·Esther K WeiJing Ma
Aug 1, 2007·Expert Review of Respiratory Medicine·Giovanni Selvaggi, Giorgio Vittorio Scagliotti
Nov 4, 2005·Investigational New Drugs·Sharon Marsh
Jun 16, 2004·International Journal of Cancer. Journal International Du Cancer·Angelo ParadisoGiuseppe Colucci
Jul 30, 2016·International Journal of Molecular Sciences·Joshua M Corbin, Maria J Ruiz-Echevarría
Feb 10, 2019·Cell Death and Differentiation·Aarif SiddiquiPaolo Ceppi
Oct 6, 2005·Journal of the National Cancer Institute·Pierpaolo CorrealeMaria Grazia Cusi
Dec 1, 2015·Future Oncology·Nataliya Uboha, Howard S Hochster
Jun 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bo LiaoXiaoping Chen
Feb 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paolo CeppiMauro Papotti
Jul 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter H O'Donnell, M Eileen Dolan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Patrick JohnstonCarmen J Allegra
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
S AguiarW J D Filho
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
David EdlerHenric Blomgren
Biochemical Society Transactions
G J Peters, C L van der Wilt
© 2021 Meta ULC. All rights reserved