Abstract
Adult T-cell leukemia-lymphoma (ATL) has been divided into 4 clinical subtypes: acute, lymphoma, chronic, and smoldering. The aim of this study is to develop a novel prognostic index (PI) for chronic and smoldering ATL. We conducted a nationwide retrospective survey on ATL patients, and 248 fully eligible individuals were used in this analysis. In the univariate analysis, sex, performance status, log10 (soluble interleukin-2 receptor [sIL-2R]), neutrophils count, and lymphadenopathy showed values of P < .05 in training samples. A multivariate analysis was performed on these factors, and only log10 (sIL-2R) was identified as an independent prognostic factor in training samples. Using a regression coefficient of this variable, a prognostic model was formulated to identify different levels of risk: indolent ATL-PI (iATL-PI) = 1.51 × log10 (sIL-2R [U/mL]). The values calculated by iATL-PI were divided into 3 groups using a quartile point. In the validation sample, median survival times (MSTs) were 1.6 years, 5.5 years, and not reached for patients in the high-, intermediate-, and low-risk groups, respectively (P < .0001). To make the scoring system clinically practicable, we simplified iATL-PI according to trichotomizing sIL-2R at ...Continue Reading
References
Nov 1, 1991·British Journal of Haematology·M Shimoyama
Sep 1, 1990·Cytokine·L A RubinG Jay
May 1, 1988·Japanese Journal of Cancer Research : Gann·T MotoiK Araki
Jun 29, 1995·The New England Journal of Medicine·P S GillS Allen
Jun 29, 1995·The New England Journal of Medicine·O HermineF Dreyfus
Mar 1, 1994·Leukemia Research·S SatoN Tsuruoka
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jun 1, 1994·Cancer·S KamihiraM Tomonaga
Jan 13, 2000·Clinical and Experimental Immunology·K ArakiT Miyakuni
Feb 13, 2001·European Journal of Haematology·N NiitsuA Chizuka
Mar 13, 2001·Bone Marrow Transplantation·A UtsunomiyaM Tomonaga
Jun 14, 2001·British Journal of Haematology·Y YamadaM Shimoyama
Jan 25, 2003·British Journal of Haematology·Masahiro KamiMasaharu Kasai
Dec 3, 2003·Blood·Andrea GallaminiUNKNOWN Intergruppo Italiano Linfomi
May 6, 2004·Blood·Philippe Solal-CélignyEmili Montserrat
Oct 27, 2004·Journal of Cancer Research and Clinical Oncology·Hideko GotoHisataka Moriwaki
Mar 4, 2005·Leukemia·T FukushimaM Tomonaga
Dec 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeeyun LeeWon Seog Kim
May 13, 2006·Leukemia & Lymphoma·Elizabeth Fabre-GuillevinPierre Soubeyran
Nov 25, 2006·Leukemia Research·Atae UtsunomiyaRyuzo Ueda
Oct 27, 2007·Blood·Eva HosterUNKNOWN European Mantle Cell Lymphoma Network
Oct 31, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kunihiro TsukasakiUNKNOWN Japan Clinical Oncology Group Study JCOG9801
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kunihiro TsukasakiToshiki Watanabe
Aug 5, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo FedericoPhilippe Solal-Céligny
Mar 30, 2010·Blood·Yumi TakasakiKunihiro Tsukasaki
May 19, 2010·Blood·Masakatsu HishizawaTakashi Uchiyama
Jun 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ali BazarbachiOlivier Hermine
Jul 2, 2011·Blood·Zhi-Zhang YangStephen M Ansell
Feb 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takashi IshidaRyuzo Ueda
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hiroo KatsuyaKazuo Tamura
Oct 5, 2014·The Lancet Oncology·Kenji Ishitsuka, Kazuo Tamura
Mar 4, 2015·British Journal of Haematology·Takashi IshidaRyuzo Ueda
Sep 13, 2015·Blood·Hiroo KatsuyaUNKNOWN ATL-Prognostic Index Project
Sep 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takashi IshidaTomoko Ohtsu
Citations
Jun 9, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Hiroo Katsuya, Kenji Ishitsuka
Mar 5, 2018·International Journal of Hematology·Hiroaki Miyoshi, Koichi Ohshima
Dec 28, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Motoko Yamaguchi
Jan 19, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lucy B CookToshiki Watanabe
Jan 19, 2019·Hematological Oncology·Ayumu KubotaAtae Utsunomiya
Jan 23, 2019·Cancer Science·Mari KannagiYouko Suehiro
Jan 13, 2018·Blood·Noriaki Yoshida, David M Weinstock
Oct 24, 2019·Cancer Science·Junya MakiyamaKaoru Uchimaru
Jan 11, 2020·Hematological Oncology·Hikaru SakamotoYasushi Miyazaki
May 6, 2020·American Journal of Clinical Pathology·Shumpei MizutaMitsumasa Watanabe
Jun 27, 2019·Cancer Science·Kazuho MorichikaHiroaki Masuzaki
Jul 9, 2020·Frontiers in Microbiology·Kunihiro TsukasakiAli Bazarbachi
Jan 27, 2019·Chinese Medical Journal·Da-Yong HuangZhao Wang
Oct 18, 2019·Frontiers in Microbiology·Lee Ratner
Apr 2, 2020·Molecular Cancer·Martina GhettiGiorgia Simonetti
Aug 17, 2020·Journal of Neuroinflammation·Haiping ZhaoYumin Luo
Jan 27, 2019·International Journal of Hematology·Hiroaki TaniguchiYasushi Miyazaki
Nov 28, 2020·The Journal of Dermatology·Mikio OhtsukaMakoto Sugaya
Feb 13, 2021·Cancer Science·Noriaki YoshidaKoichi Ohshima
Sep 27, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Lu MaWei Guo
Apr 29, 2021·Seminars in Hematology·Kenji Ishitsuka
May 1, 2021·Cancers·Noriaki YoshidaKoichi Ohshima
Apr 13, 2021·The Journal of Infectious Diseases·Hiroo KatsuyaYorifumi Satou