Prognostic indicators for breast cancer patients with one to three regional lymph node metastases, with special reference to alterations in expression levels of bcl-2, p53 and c-erbB-2 proteins

Japanese Journal of Clinical Oncology
G J ZhangS Hirohashi

Abstract

Patients with primary breast carcinoma with one to three axillary lymph node metastases but without distant metastases (n1-3) in Japan have been shown to have a 10-year disease-free survival rate of > 60%. It would be reasonable to divide n1-3 Japanese breast cancer patients into groups with high- or low-risk for recurrence and to consider post-operative adjuvant therapy. In the present study, we analyzed 228 consecutive Japanese patients with n1-3 breast cancer who underwent radical mastectomy and were followed up for a median time of 11.0 years. The expression of bcl-2, p53 and c-erbB-2 proteins in the primary tumors was examined immunohistochemically and their prognostic roles were also analyzed along with conventional clinicopathologic indicators. bcl-2 expression was correlated with positive estrogen receptor status and inversely correlated with p53, c-erbB-2 and histologic grade. Univariate analysis showed that bcl-2, p53 and c-erbB-2 expression were prognostic indicators of the patient's group as well as node status, histologic grade, tumor size, age at diagnosis, menopausal status and estrogen receptor status. Cox's regression analysis demonstrated that the number of nodes involved, menopausal status, p53 and bcl-2 were...Continue Reading

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Citations

Dec 23, 2003·Pathology Oncology Research : POR·Mansour Al-MoundhriC Grant
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M SaimuraT Nanasawa
Oct 23, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S TsutsuiS Oda
Feb 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eramah ErmiahYrjö Collan
Nov 19, 2004·Molecular Biology of the Cell·Hanane KhouryMorag Park
May 31, 2008·BMC Cancer·Grace M CallagyCarlos Caldas
Apr 24, 2008·Breast Cancer Research : BCR·Yasmine NadlerYuval Kluger
Aug 25, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hitoshi Tsuda
Mar 24, 2000·Pathology, Research and Practice·R González-CámporaA Gómez Pascual
May 16, 2007·Progress in Histochemistry and Cytochemistry·Lorenza González-MariscalErika Garay
Mar 16, 2012·International Journal of Cancer. Journal International Du Cancer·Ki-Tae HwangDong-Young Noh
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Elina ZuevaBertrand Tavitian
Jun 8, 1999·Japanese Journal of Cancer Research : Gann·T KoyamaK Mukai
Feb 2, 2010·Journal of Korean Medical Science·Kyubo KimSung W Ha

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