Prognostic markers for colorectal cancer: estimating ploidy and stroma

Annals of Oncology : Official Journal of the European Society for Medical Oncology
H E DanielsenDavid J Kerr

Abstract

We report here the prognostic value of ploidy and digital tumour-stromal morphometric analyses using material from 2624 patients with early stage colorectal cancer (CRC). DNA content (ploidy) and stroma-tumour fraction were estimated using automated digital imaging systems and DNA was extracted from sections of formalin-fixed paraffin-embedded (FFPE) tissue for analysis of microsatellite instability. Samples were available from 1092 patients recruited to the QUASAR 2 trial and two large observational series (Gloucester, n = 954; Oslo University Hospital, n = 578). Resultant biomarkers were analysed for prognostic impact using 5-year cancer-specific survival (CSS) as the clinical end point. Ploidy and stroma-tumour fraction were significantly prognostic in a multivariate model adjusted for age, adjuvant treatment, and pathological T-stage in stage II patients, and the combination of ploidy and stroma-tumour fraction was found to stratify these patients into three clinically useful groups; 5-year CSS 90% versus 83% versus 73% [hazard ratio (HR) = 1.77 (95% confidence interval (95% CI): 1.13-2.77) and HR = 2.95 (95% CI: 1.73-5.03), P < 0.001]. A novel biomarker, combining estimates of ploidy and stroma-tumour fraction, sampled fro...Continue Reading

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Citations

Jan 9, 2019·Nature Reviews. Clinical Oncology·Robert P JonesGraeme J Poston
Apr 18, 2019·JCO Clinical Cancer Informatics·Manuela SalvucciJochen H M Prehn
May 23, 2019·Molecular Cytogenetics·Andréa E TijhuisSarah E McClelland
Dec 18, 2019·International Journal of Cancer. Journal International Du Cancer·Elin ErsvaerHåvard E Danielsen
Jun 21, 2019·Gastroenterology Report·Susan FotheringhamDavid J Kerr
Sep 22, 2018·Oncotarget·Helen E J Tyrrell, David Kerr
Jul 6, 2020·Cancer Treatment Reviews·Pauline ParentAnthony Turpin
Jan 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J H Park, D C McMillan
Aug 15, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara KuntzTitus J Brinker
Jun 27, 2021·Histopathology·Helen J S JonesViktor H Koelzer

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