Prognostic markers of COPD. Role of comorbidity

Archivos de bronconeumología
Felipe Villar Alvarez, Germán Peces-Barba Romero

Abstract

A chronic disease such as chronic obstructive pulmonary disease (COPD) will inevitably have biological markers influencing its natural history or progression. The most extensively studied marker is forced expiratory volume in 1 second (FEV(1)), classically recognized as the best prognostic indicator of the disease. Other physiopathological variables are also known to have prognostic value. The course of COPD shows several distinct patterns but data are lacking on the natural history of this disease and the ability to predict which patients will show greater or lesser progression. In addition to FEV(1), there are other physiological markers of disease progression, such as gas interchange, air trapping, and pulmonary hypertension. The present article reviews the characteristics of all these markers, as well as those of two other categories: clinical markers, such as nutritional status, exercise capacity, the BODE index, which combines four physiopathological and clinical parameters, and the occurrence or absence of frequent exacerbations. Finally, a group of biological markers, potentially implicated in COPD, such as C-reactive protein, oxidative stress and other variables affecting changes in skeletal muscle, are described. COPD...Continue Reading

References

Feb 1, 1987·Annals of Internal Medicine·N R AnthonisenN A Nelson
Jul 1, 1987·The American Review of Respiratory Disease·S R SelingerJ R Michael
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·K A McCreaJ D Hasday
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·I de GodoyR M Rogers
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Jun 10, 2000·Chest·R Rodriguez-Roisin
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·S D AaronR E Dales
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Alvar G N AgustíXavier Busquets
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Antònia Domingo-SalvanyJosep M Antó
Feb 1, 2003·European Journal of Applied Physiology·Luis Puente-MaestuWilliam W Stringer
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
May 22, 2003·The New England Journal of Medicine·Alfred FishmanUNKNOWN National Emphysema Treatment Trial Research Group
May 27, 2003·The European Respiratory Journal·J A BarberàS Santos
Jul 2, 2004·American Journal of Respiratory and Critical Care Medicine·Don D SinS F Paul Man
Aug 23, 2005·Proceedings of the American Thoracic Society·S F Paul Man, Don D Sin
Sep 9, 2006·Medicine and Science in Sports and Exercise·Hanneke A C Van HelvoortP N Richard Dekhuijzen
Jun 19, 2008·Archivos de bronconeumología·Joaquim Gea, Esther Barreiro

❮ Previous
Next ❯

Citations

Mar 19, 2014·Semergen·J T Gómez SáenzR Hernández García
Jan 7, 2015·Clinical Biochemistry·Paloma OliverJose Manuel Iturzaeta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved