Prognostic model for patient survival in primary anorectal mucosal melanoma: stage at presentation determines relevance of histopathologic features.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Priyadharsini NagarajanMichael T Tetzlaff

Abstract

Pathological staging of primary anorectal mucosal melanoma is often performed according to the American Joint Commission on Cancer (AJCC) guidelines for cutaneous melanoma, as an anorectal melanoma-specific staging system does not exist. However, it remains unknown whether prognostic factors derived for cutaneous melanoma also stratify risk in anorectal melanoma. We retrospectively determined correlations between clinicopathological parameters and disease-specific survival in 160 patients. Patients were grouped by clinical stage at presentation (localized disease, regional or distant metastases). Cox proportional hazards regression models determined associations with disease-specific survival. We also summarized the somatic mutations identified in a subset of tumors analyzed for hotspot mutations in cancer-associated gene panels. Most of the patients were white (82%) and female (61%). The median age was 62 years. With a median follow-up of 1.63 years, median disease-specific survival was 1.75 years, and 121 patients (76%) died of anorectal melanoma. Patients presenting with regional (34%) or distant metastases (24%) had significantly shorter disease-specific survival compared to those with disease localized to the anorectum (42...Continue Reading

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Citations

Jul 28, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·So-Woon KimIn Ja Park
Sep 21, 2020·Archives of Medical Research·Carlos Torres-CabalaWen-Jen Hwu
Nov 7, 2021·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Jin Cheon KimIn Ja Park

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