Prognostic models for the probability of achieving an ongoing pregnancy after in-vitro fertilization and the importance of testing their predictive value

Human Reproduction
A M StolwijkA L Verbeek

Abstract

The aim of this study was to create reliable models to predict the probability of achieving an ongoing pregnancy during in-vitro fertilization (IVF) treatment: model A, at the start of the first treatment, model B at the time of embryo transfer, and model C, during the second treatment at the end of the first IVF treatment. Prognostic models were created using data from the University Hospital Nijmegen (n = 757) and applied to the data from the Catharina Hospital Eindhoven (n = 432), The Netherlands, to test their predictive performance. The predictions of model B (made at time of embryo transfer) were fairly good (c = 0.672 in the test population). For instance, 93% of the patients who had a predicted probability of achieving an ongoing pregnancy of < 10% did not achieve an ongoing pregnancy. However, the predictions of the other two models (A and C) for Eindhoven were less reliable. The predictive value of model C was fairly high in Nijmegen (c = 0.673). Its poor performance in the test population may be explained partly by differences in effectiveness of the ovulation stimulation protocols and the decision about when to discontinue the cycle. Thus, before using prognostic models at an IVF centre, their reliability at that sp...Continue Reading

Citations

Jan 23, 2014·Reproductive Biomedicine Online·Piraye Yurttas BeimTina T Hu-Seliger
Sep 7, 2002·Fertility and Sterility·Claudine C HunaultJ Dik F Habbema
Jul 27, 2001·Journal of Clinical Epidemiology·E W SteyerbergJ D Habbema
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Prajna BanerjeeMylene W M Yao
Jun 24, 2008·Human Fertility : Journal of the British Fertility Society·Abha MaheshwariNeil P Johnson
Feb 15, 2002·Human Fertility : Journal of the British Fertility Society·Ben W. J. MolEwout W. Steyerberg
Nov 28, 2012·Journal de gynécologie, obstétrique et biologie de la reproduction·P ArvisP Lehert
Feb 15, 2011·Reproductive Biomedicine Online·A La MarcaA Volpe
Oct 6, 2010·Cancer·Petra BiewengaMarrije R Buist
Mar 20, 2010·Reproductive Biomedicine Online·Göran PetterssonJoan-Carles Arce
Sep 11, 2009·Gynecologic Oncology·Petra BiewengaMarrije R Buist
Feb 17, 2015·Journal of Advanced Research·Laura van LoenderslootM van Wely
May 8, 2016·Journal of Assisted Reproduction and Genetics·Marni B JacobsV Gabriel Garzo
Jun 29, 2010·Human Reproduction Update·L L van LoenderslootF van der Veen
May 14, 2009·Human Reproduction Update·Esther LeushuisPeter G A Hompes
Jul 11, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J W van der SteegB W J Mol
Apr 2, 2005·Human Reproduction·C GnothG Freundl
Sep 26, 2006·Human Reproduction·J W van der SteegUNKNOWN CECERM study group (Collaborative Effort for Clinical Evaluation in Reproductive Medicine)
Jun 10, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tevfik Yoldemir
Nov 13, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·A L RichardsonA H Balen
Aug 8, 2006·Human Reproduction Update·F J BroekmansC B Lambalk
Apr 9, 2005·Human Reproduction·A M E LintsenF E van Leeuwen
Apr 6, 2019·Combinatorial Chemistry & High Throughput Screening·Boyun XuJunzhao Zhao
Aug 27, 2005·Human Reproduction·L AnderheimA Möller
Aug 5, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Antonio La MarcaSesh Kamal Sunkara

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