Prognostic models in the myeloproliferative neoplasms.

Blood Reviews
Jacob Grinfeld

Abstract

The management of myelofibrosis (MF) is predominantly supportive, with the use of JAK2 inhibitors or allogeneic stem cell transplantation reserved for patients predicted to have poor overall survival. Identification of these patients is aided by a number of prognostic scoring systems, foremost among them the Dynamic International Prognostic Scoring System (DIPSS). Similarly, the use of cytoreductive therapies in essential thrombocytosis (ET) and polycythemia vera (PV) is targeted to patients identified as at highest risk of thrombosis. In this context, age and history of prior thrombosis are the strongest risk factors. Several studies have sought to improve the accuracy of prognostic modelling by encorporating a wider range of clinical and genomic variables, while also assessing those predictive for other endpoints, such as disease transformation. This review aims to summarise and evaluate existing prognostic models in the myeloproliferative neoplasms, and examine ways in which they can be further refined.

Citations

Oct 21, 2020·Expert Review of Hematology·Jan Philipp Bewersdorf, Amer M Zeidan
Apr 22, 2021·HemaSphere·Andrew J Robinson, Anna L Godfrey
May 30, 2021·Annales pharmaceutiques françaises·M Arock
Aug 20, 2021·British Journal of Haematology·Nicholas C P CrossUNKNOWN A British Society for Haematology Good Practice Paper
Aug 18, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anish V ShardaJeffrey I Zwicker

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