Prognostic Nomograms Predicting Survival in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: The First Nomogram Compared With Revised FIGO 2018 Staging System

Frontiers in Oncology
Xi YangLingying Wu

Abstract

To develop nomograms to assess prognostic factors for 5-year overall survival (OS) and 5-year progression-free survival (PFS) in locally advanced cervical squamous cell carcinoma (LACSC). Overall, 618 patients with LACSC were included in this retrospective analysis. Nomograms for 5-year OS and PFS were developed based on Cox proportional hazards regression models. Concordance index (C-index) and calibration curves were used to define the predictive and discriminatory capacity of the nomogram. A comparison between the nomogram and the International Federation of Gynecology and Obstetrics (FIGO) staging system was conducted using time-dependent receiver operating characteristic (tROC) and area under the curve (tAUC). Multivariate analysis identified several prognostic factors for OS including squamous cell carcinoma antigen (SCC-Ag), body mass index (BMI), tumor size, pelvic wall involvement, and para-aortic lymph node metastasis (PALNM). Prognostic factors for PFS included BMI, hemoglobin (HGB), tumor size, pelvic wall involvement, pelvic lymph node metastasis (PLNM) and PALNM. Following bootstrap correction, the C-index of OS and PFS was 0.713 and 0.686, respectively. These nomograms showed superior performance compared with th...Continue Reading

References

Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·T NakanoK Oka
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L C WongD T Choy
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Anurag K SinghBarry A Siegel
Jul 5, 2003·Lancet·Steven E Waggoner
Jun 21, 2005·Nature Reviews. Cancer·Jerry L Spivak
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration
Apr 16, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio Pecorelli
Mar 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A KiddPerry W Grigsby
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·YoungSeok SeoChul-Koo Cho
Apr 12, 2013·Future Medicinal Chemistry·Sarah K BurroughsBinghe Wang
Oct 30, 2013·Journal of Gynecologic Oncology·Byoung-Gie Kim
Mar 19, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN FIGO Committee on Gynecologic Oncology
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Carla Rameri Alexandre Silva de AzevedoCarlos Gil Ferreira
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Neerja BhatlaRengaswamy Sankaranarayanan
Nov 6, 2018·Gynecologic Oncology·Koji MatsuoMikio Mikami
Jan 19, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Neerja BhatlaJayashree Natarajan

❮ Previous
Next ❯

Software Mentioned

R
SPSS Statistics

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

© 2021 Meta ULC. All rights reserved