Prognostic nutritional index predicts survival and correlates with systemic inflammatory response in advanced pancreatic cancer

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Y GengZ Chen

Abstract

Recent studies have implied a prognostic value of the prognostic nutritional index (PNI) in certain types of human cancers. However, the value of PNI for predicting survival in patients with pancreatic cancer remains unknown. The goal of this study was to investigate the predictive significance of PNI in patients with advanced pancreatic cancer. A total of 321 consecutive patients with pathologically-confirmed locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) were retrospectively recruited between January 2011 and August 2013. The patients were divided into a test set (n = 110) and a validation set (n = 211). We evaluated the association between PNI and overall survival (OS). The relationship between PNI and systemic inflammatory response markers, including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte ratio (LMR) was also assessed. In addition, the associations between PNI and the TNF-α were analyzed. Kaplan-Meier analyses showed that a low PNI correlated significantly with a shorter OS in patients with advanced pancreatic cancer (190 days for patients with a low PNI vs. 290 days for patients with a high PNI, log-rank = 12.566, P < 0.001). Multivariate anal...Continue Reading

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Citations

Oct 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan DengChang Liu
Dec 15, 2016·Nutrition and Cancer·Sang Hoon LeeJae Bock Chung
Jul 12, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Gardner YostGeetha Bhat
Jul 20, 2018·Clinical and Experimental Otorhinolaryngology·Marn Joon ParkSoon Yuhl Nam
Oct 11, 2019·Therapeutic Advances in Medical Oncology·Aurélien LambertThierry Conroy
Nov 28, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Massimiliano SalatiAndrea Casadei-Gardini
Feb 7, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dong WangLeDu Zhou
Mar 10, 2020·World Journal of Gastroenterology : WJG·Shuai-Shuai XuXian-Jun Yu
Jan 28, 2017·World Journal of Gastroenterology : WJG·Hao-Jun ShiDe-Liang Fu
Apr 18, 2020·Asia-Pacific Journal of Clinical Oncology·Gokhan UcarDogan Uncu
Apr 30, 2019·Nutrition and Cancer·Nélia Pinheiro MendesSylvia do Carmo Castro Franceschini
Apr 17, 2019·Acta Diabetologica·Valentina PasqualeLorenzo Piemonti
Jul 7, 2017·Journal of Gastric Cancer·Ki Hyun KimHyung Ho Kim
Nov 12, 2020·Journal of Hepato-biliary-pancreatic Sciences·Yong Chan ShinJin-Young Jang
Sep 27, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Tomoyuki AbeToshio Noriyuki
Apr 6, 2021·Journal of Cardiovascular and Thoracic Research·Hilal Erken PamukcuSadık Açıkel

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