PMID: 8952563Dec 15, 1996Paper

Prognostic parameters for survival of patients with malignant mesenchymal tumors of the uterus

Cancer
M NolaS Jukić

Abstract

Malignant mesenchymal uterine neoplasms are the most aggressive type of primary uterine tumors, with most patients dying within a few years of diagnosis. Thus, it would be very important to define prognostic factors for predicting the malignancy potential of at least some of their subtypes. Flow cytometric cell cycle analysis (proliferative activity, DNA ploidy, and DNA index) was performed on archival paraffin embedded blocks from 80 patients with malignant mesenchymal uterine neoplasms (endometrial stromal sarcomas, malignant smooth muscle tumors, and malignant Müllerian mixed tumors). The Cox proportional hazards regression model was used to assess relative effects of the following factors on patient survival: clinical stage, mode of therapy, DNA+proliferative activity, DNA index, histologic type, cellularity, degree of atypia, mitotic activity, and depth of myometrial invasion. There were 9 low grade stromal sarcomas, 17 high grade stromal sarcomas, 8 smooth muscle neoplasms with uncertain malignant potential, 23 leiomyosarcomas, and 16 homologous and 7 heterologous malignant Müllerian mixed tumors. In univariate analysis for stromal sarcomas, statistical significance was found for DNA ploidy+proliferative activity (P < 0.0...Continue Reading

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Citations

Aug 19, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Woo Young KimHee-Sug Ryu
Jan 27, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K-L J Kelly, P S Craighead
Dec 1, 2009·Surgical Pathology Clinics·Esther Oliva, Patricia M Baker
Feb 8, 2005·Histopathology·H Fox
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Jul 27, 1999·Gynecologic Oncology·K MayerhoferC Kainz
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Feb 25, 2010·Advances in Anatomic Pathology·Ivy Chew, Esther Oliva
Sep 24, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jose Alejandro Rauh-HainMarcela G del Carmen
May 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jose Alejandro Rauh-HainMarcela G del Carmen
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Manuela PelmusGaëtan MacGrogan
Mar 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Izaskun ValduviecoAlbert Biete
May 27, 2010·Archives of Gynecology and Obstetrics·Alexandros DafopoulosAlexander Tobias Teichmann
Jul 17, 1999·British Journal of Cancer·Y L ZhaiS Fujii
Jun 29, 2017·Journal of Gynecologic Oncology·Ayami InoueNoriomi Matsumura
Aug 17, 2019·World Journal of Clinical Cases·Alessandro RizzoMargherita Nannini
Feb 10, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W KildalH E Danielsen

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