Abstract
We undertook a systematic evaluation of the prognostic value of numerous histological factors in 165 radical cystectomies (RCs) of patients with invasive urothelial carcinoma (UC) who underwent surgery after neoadjuvant chemotherapy (NAC). Tumour regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0 + pN0), and 28% had no evidence of residual muscle-invasive carcinoma (≤pT1 + N0). TRG1, TRG2 and TRG3 were found in 32%, 15% and 50% of patients, respectively. Histological variants of UC were reported in 25% of cases. The most common therapy-related stromal change was fibroblastic reaction (78%), and the most common epithelial change in residual UC was smudgy and poorly preserved chromatin (28%). Prominent stromal and epithelial changes were noted in 41% and 5% of RCs, respectively. Progression was found in 45% of patients, and cancer-related deaths occurred in 30%. Multivariate analysis showed that the only independent prognostic parameters for progression were T stage, N stage, lymphovascular invasion, and margin status. Similarly, only T stage, N stage and margin statu...Continue Reading
References
Jun 1, 1994·Cancer·A M MandardG Samama
Jul 4, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F C EilberF R Eilber
Jul 18, 2001·Annals of Surgical Oncology·R M HenshawM M Malawer
Jan 5, 2002·Journal of the National Cancer Institute. Monographs·N WolmarkB Fisher
Jun 13, 2003·Lancet·UNKNOWN Advanced Bladder Cancer Meta-analysis Collaboration
Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Sep 26, 2003·Cancer·Karen BeckerHeinz Höfler
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Keith N OgstonSteven D Heys
Mar 27, 2004·The American Journal of Surgical Pathology·Jinru ShiaDavid S Klimstra
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry W HerrE David Crawford
Sep 1, 2004·Clinical Breast Cancer·Radhika RajanW Fraser Symmans
Jun 12, 2009·Cancer·Guru SonpavdeE David Crawford
Dec 18, 2010·The American Journal of Surgical Pathology·Jinru ShiaDavid S Klimstra
Dec 21, 2010·BJU International·Faysal A YafiWassim Kassouf
Jan 14, 2012·Virchows Archiv : an International Journal of Pathology·Runjan ChettyLai Mun Wang
Apr 16, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Peter E ClarkUNKNOWN National Comprehensive Cancer Network (NCCN)
Oct 11, 2013·Frontiers in Oncology·Svenja Thies, Rupert Langer
Feb 15, 2014·The American Journal of Surgical Pathology·Achim FleischmannRoland Seiler
Mar 31, 2015·Urologic Oncology·Nilay M GandhiTrinity J Bivalacqua
Nov 3, 2015·The Journal of Urology·Homayoun ZargarUNKNOWN Collaborators
Dec 25, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E WardelmannS Bonvalot
Mar 16, 2016·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Wassim KassoufD Robert Siemens
Mar 22, 2016·European Urology·Peter A HumphreyVictor E Reuter
Jun 21, 2016·Human Pathology·Hui Jun WangFadi Brimo
Sep 19, 2016·Urologic Oncology·Aaron BrantTrinity J Bivalacqua
Mar 30, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G TomaselloS Barni
Jun 19, 2017·World Journal of Urology·Homayoun ZargarWassim Kassouf
Citations
Oct 7, 2018·Histopathology·Bernard MalavaudMarie-Laure Ranty
Sep 17, 2019·The American Journal of Surgical Pathology·Charlotte S VoskuilenRoland Seiler
Apr 24, 2019·World Journal of Urology·Xueming LinChin-Lee Wu
Nov 17, 2020·Frontiers in Genetics·Xin Pan, Xiaoxin Ma
Feb 10, 2021·Diagnostics·Kei YonedaHiroyoshi Suzuki
Aug 13, 2020·Clinical Genitourinary Cancer·Marina DeukerPierre I Karakiewicz
Mar 19, 2021·Anti-cancer Drugs·Shunying WeiLiehong Wang
Jun 19, 2021·Frontiers in Oncology·Yonghe ChenJunsheng Peng
Sep 24, 2021·World Journal of Urology·Eva CompératMahul B Amin