Prognostic power of Doppler perfusion index in colorectal cancer. Correlation with survival

Annals of Surgery
E LeenC S McArdle

Abstract

The authors assessed the relative value of Dukes' staging and Doppler perfusion index (DPI) as prognostic indices of early death in patients with colorectal cancer who have had apparently curative surgery. Dukes' classification is recognized as the gold standard against which other prognostic factors should be compared; however, its discriminatory power is limited. No established method exists for accurately identifying patients who, despite having undergone an apparently curative resection for colorectal carcinoma, are at high risk. Eighty consecutive patients undergoing apparently curative surgery for colorectal cancer were staged using Dukes' classification. In addition, DPI (ratio of hepatic arterial to total liver blood flow) was measured before surgery by means of a duplex/color Doppler sonography. On the basis of 2-year follow-up data, Dukes' classification failed to define clearly those patients who died or who developed recurrent disease. In contrast, DPI clearly identified two groups of patients: 78% of patients with an abnormally elevated DPI value developed recurrent disease or died, whereas 97% of patients with a normal DPI value survived. This technique can identify patients at high risk for colorectal cancer, aft...Continue Reading

References

Nov 1, 1992·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·J RobertsonC S McArdle
Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Jan 1, 1990·Nuclear Medicine Communications·K C BallantyneJ D Hardcastle
Oct 1, 1986·Journal of Clinical Ultrasound : JCU·F MoriyasuS Koizumi
Jun 24, 1988·JAMA : the Journal of the American Medical Association·M BuyseT C Chalmers
Sep 1, 1986·The British Journal of Surgery·I G Finlay, C S McArdle
Feb 1, 1985·The British Journal of Surgery·S H LevesonP J Robinson

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Citations

Jul 20, 2010·European Journal of Nuclear Medicine and Molecular Imaging·David Cosgrove, Nathalie Lassau
May 9, 2006·Archives of Gynecology and Obstetrics·Ikuno KawabataToshiyuki Takeshita
May 5, 2000·Ultrasound in Medicine & Biology·M LafortuneM Dauzat
Jan 1, 1997·Surgical Oncology·T J HughG J Poston
Aug 10, 1999·Critical Reviews in Oncology/hematology·A R Padhani
Nov 17, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A I SarelaP J Guillou
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R M AnwarW Stevens
Nov 26, 2010·Investigative Radiology·Balaji GaneshanKenneth Miles
Oct 9, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ken Miles, Guy Burkill
Jul 1, 1997·The Australian and New Zealand Journal of Surgery·T J Hugh, G J Poston
Mar 1, 2005·Radiology·Pari V PandharipandeVivian S Lee
Mar 27, 2007·Digestive Diseases·A H KarantanasN Gourtsoyiannis
Nov 30, 2007·Acta chirurgica Iugoslavica·S Stojcić DjenićV Jurisić
Jul 21, 2006·The British Journal of Radiology·M J WhiteJ J Totman
May 7, 2004·Radiology·Jonathan B KruskalS Nahum Goldberg
Sep 26, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·W Phillip Law, Kenneth A Miles
Aug 21, 2007·Academic Radiology·Balaji GaneshanChris R Chatwin
Jun 12, 2014·La Radiologia medica·Amir Reza RadmardAmir Pejman Hashemi Taheri
Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R M H RoumenA W M van der Linden
Apr 25, 2006·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Suna Ozhan OktarHakan Ozdemir
Jun 2, 1998·The British Journal of Surgery·A ShankarI Taylor

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