Prognostic predictive value of preoperative intratumoral 2-deoxy-2-(18F)fluoro-D-glucose uptake heterogeneity in patients with high-grade serous ovarian cancer

Nuclear Medicine Communications
Shuai LiuXiaohua Wu

Abstract

This study aimed to explore the clinical and prognostic significance of pretreatment positron-emission tomography/computed tomography (PET/CT) parameters, especially 2-deoxy-2-(F)fluoro-D-glucose-based heterogeneity, in high-grade serous ovarian cancer (HGSC). We retrospectively investigated 56 patients with HGSC who underwent PET/CT before primary surgery at our hospital between January 2010 and June 2015. None of these patients received neoadjuvant chemotherapy. PET/CT parameters, including maximum and mean standardized uptake value (SUVmax and SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and intratumoral heterogeneity index (HI), were measured for all patients. Differences of each PET/CT parameter between primary tumors (-P) and omental metastatic lesions (-M) were compared by paired t tests. Progression-free survival (PFS) and overall survival were analyzed by the Kaplan-Meier method and log-rank tests in univariate analyses. Cox regression analyses were used for multivariate analysis. SUVmean-P was higher than SUVmean-M (P=0.001). However, there were no statistical differences of SUVmax, MTV, TLG, or HI between primary and omental lesions. Chemosensitive patients tended to have higher levels of SU...Continue Reading

References

Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Norbert AvrilWalther Kuhn
Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
Feb 16, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Florent TixierDimitris Visvikis
May 28, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Floris H P van VeldenRonald Boellaard
Nov 22, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Manushka VaidyaIssam El Naqa
Oct 4, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jonathan S BerekMichael Friedlander
Oct 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Sugama ChickloreGary J R Cook
Dec 4, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gary J R CookDavid Landau
Dec 13, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Johannes SalamonVictor F Mautner
Jan 28, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yuko TanizakiKazuhiko Ino
Apr 23, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kyoungjune PakDong Soo Lee
May 24, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Jeong Won LeeWon Jun Kang
Jul 6, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Haruhisa KonishiYoshifumi Sugawara
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jan 16, 2016·Journal of Gynecologic Oncology·Hyun Hoon ChungGi Jeong Cheon

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Citations

Dec 5, 2019·Cancer Biomarkers : Section a of Disease Markers·Shuang YeHuijuan Yang

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