Prognostic relevance of ductal margins in operative resection of bile duct cancer

Surgery
Ryota HiguchiMasakazu Yamamoto

Abstract

The clinical relevance of the ductal margins in operative resection of bile duct carcinoma has not been well established. The purpose of this study was to assess the prognostic significance of ductal margins in patients with bile duct carcinoma. A total of 256 patients with bile duct carcinoma were analyzed retrospectively. We compared clinicopathologic features, outcomes, and recurrences among patients who underwent curative resections with free margins (D-FRE: n = 185), noncurative resections only resulting from the involvement of ductal margins with carcinoma in situ (D-CIS: n = 13), noncurative resections only caused by the involvement of ductal margins with invasive foci of carcinoma (D-INV: n = 17), and noncurative resections resulting from any other margin state and/or distant metastases (OTH: n = 41). Histologic grades, node involvements, T classifications, and JSBS staging were significantly associated with the ductal margin state. The 5-year survival rate by Kaplan-Meier analysis was 54.7%, 52.4%, 17.6%, and 16.7% for patients with D-FRE, D-CIS, D-INV, and OTH, respectively. A multivariate analysis by the Cox proportional hazards model has shown that, in addition to lymph node involvement (P = 6.6 x 10(-4)) and venous...Continue Reading

References

Apr 1, 1992·Annals of Surgery·M R BhuiyaS Shionoya
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Jan 24, 2003·Journal of Hepato-biliary-pancreatic Surgery·Takukazu NagakawaYoshio Yamaoka
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Koji YamaguchiMasao Tanaka
Jun 11, 2008·Annals of Surgical Oncology·Itaru EndoWilliam R Jarnagin
Feb 13, 2009·Annals of Surgery·Tsuyoshi IgamiYoshie Shimoyama

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Citations

Dec 7, 2013·World Journal of Surgery·Norihiko FurusawaSin-ichi Miyagawa
Sep 4, 2014·International Journal of Surgery·Andrea CavallaroAlessandro Cappellani
Nov 1, 2015·Langenbeck's Archives of Surgery·Fumihiko MiuraTadahiro Takada
Jan 22, 2014·Journal of Hepato-biliary-pancreatic Sciences·Toru FurukawaMasakazu Yamamoto
Mar 19, 2015·Journal of Hepato-biliary-pancreatic Sciences·Hideyuki YoshitomiMasaru Miyazaki
Mar 20, 2015·Journal of Hepato-biliary-pancreatic Sciences·Masaru MiyazakiTadahiro Takada
Dec 6, 2014·Diagnostic Cytopathology·Kiyoshi ToneAkira Kurose
May 27, 2014·International Journal of Hepatology·Yasuni NakanumaMotoko Sasaki
May 21, 2016·Journal of Surgical Oncology·Faiz GaniTimothy M Pawlik
Jan 25, 2017·The British Journal of Radiology·Yi-Jun KimEun Mi Nam
Feb 2, 2018·Molecular and Clinical Oncology·Kensuke OkanoHiroshi Kijima
Sep 22, 2018·Annals of Gastroenterological Surgery·Toshifumi WakaiTakashi Kobayashi

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