Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms

European Journal of Endocrinology
Vince Kornél GrolmuszAttila Patócs

Abstract

Objective Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas, however their prognosis differs significantly upon their proliferative state which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to identify miRNAs with altered expression upon proliferation which can be used as prognostic biomarkers in PanNENs. Methods MiRNA expression profiles of 40 PanNENs were downloaded from Gene Expression Omnibus and were reanalyzed upon tumor grades (discovery cohort). Results of the reanalysis were confirmed by qRT-PCR analysis of 5 miRNAs on an independent validation cohort of sixty three primary PanNEN samples. Cox proportional hazards survival regression model was fit for both univariate and multivariate analysis to determine the miRNAs' effect on progression-free and overall survival. Results 19 miRNAs displayed differential expression between tumor grades. The altered expression of 3 out of 5 chosen miRNAs was successfully validated; hsa-miR-21, hsa-miR-10a and hsa-miR-106b were up-regulated in more proliferative PanNENs compared to grade 1 tumors. In univariate analysis, higher expression of tis...Continue Reading

References

Mar 3, 2006·Genes & Development·Marco Antonio Valencia-SanchezRoy Parker
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudia RoldoCarlo M Croce
Nov 10, 2007·The Journal of Biological Chemistry·Lisa B FrankelAnders H Lund
Jun 3, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T R HalfdanarsonG M Petersen
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edoardo MissiagliaAldo Scarpa
Dec 17, 2009·Cancer Metastasis Reviews·Sylvia K Shenouda, Suresh K Alahari
Sep 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zsófia TömbölPeter Igaz
May 8, 2013·Journal of Neurotrauma·Jian-Zhong HuHong-Bin Lu
Dec 9, 2014·Annals of Surgical Treatment and Research·Tae Ho Hong, Il Young Park
Jun 18, 2015·Drug Development Research·Susan R PfefferLawrence M Pfeffer
Mar 16, 2016·BMC Cancer·Oscar Peralta-ZaragozaCarlos Pérez-Plasencia
Feb 16, 2017·Nature·Aldo ScarpaSean M Grimmond
Apr 16, 2017·Molecular Cancer·Ashley Di MeoGeorge M Yousef
Jun 10, 2017·Virchows Archiv : an International Journal of Pathology·Vince Kornél GrolmuszAttila Patócs
Sep 29, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yiying WuLiming Zhou

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