Prognostic Role of a Multimarker Analysis of Circulating Tumor Cells in Advanced Gastric and Gastroesophageal Adenocarcinomas

Oncology
Ilja KubischUlrich Stölzel

Abstract

We aimed to assess the prognostic value of circulating tumor cells (CTC) in patients with advanced gastric and gastroesophageal adenocarcinomas. The presence of CTC was evaluated in 62 patients with advanced gastric and gastroesophageal adenocarcinomas before systemic therapy and at follow-up through immunomagnetic enrichment for mucin 1- and epithelial cell adhesion molecule (EpCAM)-positive cells, followed by real-time RT-PCR of the tumor-associated genes KRT19, MUC1, EPCAM, CEACAM5 and BIRC5. The patients were stratified into groups according to CTC detection (CTC negative: with all marker genes negative; CTC positive: with at least 1 of the marker genes positive). Patients who were CTC positive at baseline had a significantly shorter median progression-free survival (PFS; 3.5 months, 95% CI: 2.9-4.2) and overall survival (OS; 5.8 months, 95% CI: 4.5-7.0) than patients lacking CTC (PFS 10.7 months, 95% CI: 6.9-14.4, p<0.001; OS 13.3 months, 95% CI: 8.0-18.6, p=0.003). Alterations in the marker profile during the course of chemotherapy were not predictive of clinical outcome or response to therapy. Yet, a favorable clinical response depended significantly on CTC negativity (p=0.03). Our data suggest that the presence of CTC i...Continue Reading

Citations

Aug 17, 2016·International Journal of Molecular Sciences·Giulia Gallerani, Francesco Fabbri
Aug 20, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Andreia M SousaFilipe Santos-Silva
Dec 6, 2017·Expert Review of Anticancer Therapy·Anthony LopezJaffer A Ajani
Mar 31, 2018·Oncotarget·Camila Tavares Uchôa GuimarãesDanielle Queiroz Calcagno
Mar 31, 2017·Molecular and Clinical Oncology·Yongping LiuChangsong Zhang

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