Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease

International Journal of Cardiology
Attila NemesMiklós Csanády

Abstract

The degree of aortic atherosclerosis (AA) and coronary flow reserve (CFR) can be evaluated simultaneously during the same transoesophageal echocardiographic (TEE) examination. The aim of the present study was to assess the relative prognostic value of simultaneously evaluated CFR and AA by TEE in patients with suspected or known coronary artery disease (CAD). The present study comprised 397 inhospital patients with chest pain. All patients underwent a transthoracic echocardiographic study to evaluate left ventricular function and a vasodilator TEE study to evaluate simultaneously CFR and the degree of AA. Coronary angiography was performed in 292 patients (74%). Significant CAD was less frequent in patients with normal CFR and low-grade AA. During a mean follow-up of 41+/-12 months, 23 patients suffered cardiovascular death (14 sudden cardiac death, 7 heart failure, 2 cardiovascular thrombosis). Univariate analysis yielded age, diabetes, AA grade and CFR as predictors of survival. Multivariate regression analysis showed that only CFR (hazard ratio (HR) 2.9, P<0.02) and diabetes (HR 3.8, P<0.01) were independent predictors of survival. It can be said that both CFR and AA grade are associated with poor survival but only CFR is an...Continue Reading

References

Jun 14, 1979·The New England Journal of Medicine·G A Diamond, J S Forrester
Oct 1, 1990·Circulation·O M HessG B Mancini
Jan 1, 1993·Journal of the American College of Cardiology·G P FazioN B Schiller
Nov 9, 2004·The International Journal of Cardiovascular Imaging·Attila NemesNoémi Gruber
Jan 13, 2005·Seminars in Nuclear Medicine·Josef Machac
Dec 13, 2005·Stroke; a Journal of Cerebral Circulation·R Parker WardRoberto M Lang

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Citations

Jul 10, 2018·Current Opinion in Cardiology·Janet WeiC Noel Bairey Merz
Nov 28, 2012·Orvosi hetilap·Attila Nemes, Tamás Forster

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