Abstract
Overexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in Taiwan. We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections. Positive pc-Jun staining was observed in 42 of 70 (60%) cases of oral SCC. No significant correlation was found between pc-Jun expression and patients' age, gender, oral habit, cancer location, clinical stage, tumor size and lymph node status. Kaplan-Meier curves showed that oral SCC patients with positive pc-Jun staining or positive lymph node metastasis had significantly shorter overall survival (p < 0.018 and 0.001, respectively, by log-rank test). These results indicate that c-Jun activation may play an important role in the carcinogenesis of oral SCC. Positive pc-Jun staining may serve as an adjuvant marker of worse prognosis in patients with oral SCC in Taiwan.
References
Jul 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoS F Hsieh
Dec 12, 1991·Nature·T SmealM Karin
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T S HuangJ K Lin
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J SchütteM J Birrer
Jul 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M Y KuoC P Chiang
Dec 1, 1994·British Journal of Urology·D G TiniakosC H Horne
Nov 1, 1995·European Journal of Cancer. Part B, Oral Oncology·C RivaC Brambilla
Jul 1, 1997·Molecular Carcinogenesis·Z DongN H Colburn
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R YoungN Colburn
Nov 11, 1999·Oncogene·L M SmithM J Birrer
Feb 24, 2000·Gynecologic Oncology·K P NephewN Husseinzadeh
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·J M GeeR I Nicholson
Jun 13, 2000·Oncogene·A BehrensE F Wagner
Jan 10, 2001·Cancer·M F YuenC L Lai
Jun 13, 2001·Oncogene·E Shaulian, M Karin
Mar 20, 2002·The Journal of Biological Chemistry·Kotha SubbaramaiahAndrew J Dannenberg
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Aug 26, 2003·The American Journal of Pathology·Stefan KinsJürgen Götz
Citations
Jul 24, 2008·Histochemistry and Cell Biology·James W Mandell
Sep 19, 2012·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Gunjan ShahSagar Vaishampayan
Dec 19, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Joelma Sousa LimaSuzana C Orsini Machado de Sousa
Aug 30, 2008·Cancer Science·Yin-Ju ChenAnn-Joy Cheng
Sep 18, 2009·Experimental Dermatology·Zuzana MarcekováRudolf A Rupec
Oct 7, 2016·Scientific Reports·Ila PantPaturu Kondaiah
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ioannis Gkouveris, Nikolaos G Nikitakis
Nov 17, 2017·Journal of Immunoassay & Immunochemistry·Asmaa Gaber AbdouEnas Abouelfath