Prognostic Role of Conventional and Dynamic Contrast-Enhanced MRI in Optic Pathway Gliomas

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Nutchawan JittapiromsakT Linda Chi

Abstract

The natural history of optic pathway glioma (OPG) is highly variable and unpredictable. We present a pilot study of the prognostic role of conventional and dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in the evaluation of OPG. We retrospectively reviewed 17 patients with 20 pretreatment OPG lesions who underwent conventional and DCE MRI between January 2010 and December 2016. Conventional MRI was evaluated for enhancement pattern, cystic component, optic nerve tortuosity, optic nerve dural ectasia, and optic nerve perineural thickening. The DCE MRI data were analyzed for quantitative parameters using the two-compartment pharmacokinetic model (Ktrans , kep , and ve ) and for semiquantitative parameters based on time-signal intensity curve (AUC60 , peak, and wash-in). The results were compared with the clinically progressive or nonprogressive tumor. Five progressive OPGs and 15 nonprogressive OPGs were included. Conventional MRI findings of diffuse enhancement and cystic component were significantly correlated with progressive OPGs (both P = .01). Conventional MRI yielded sensitivity of 60%, specificity of 100%, and accuracy of 90%. Ktrans , kep , and ve as well as AUC60 , peak, and wash-in were significantly hi...Continue Reading

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Citations

Jul 5, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Jingjing ZhangXiaoyuan Chen
Jun 18, 2021·Journal of Neuroendocrinology·Emilia SbardellaUNKNOWN Talent group

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