Prognostic role of Helicobacter pylori infection in acute coronary syndrome: a prospective cohort study.

Cardiovascular Journal of Africa
R EskandarianM Madani

Abstract

In a prospective cohort study, we evaluated the effect of Helicobacter pylori seropositivity on the risk of future adverse cardiovascular outcomes among patients with acute coronary syndrome (ACS). In 433 patients, IgA and IgG antibodies to H pylori, along with classic risk factors, including hypertension, diabetes, hyperlipidaemia, smoking and family history of coronary artery disease (CAD) were determined. Short and long-term follow-up information on adverse outcomes, defined as recurrence of unstable angina, myocardial infarction, coronary angioplasty, coronary artery bypass graft surgery, and sudden cardiac death was obtained. None of the classic CAD risk factors correlated with incidence of either short- or long-term outcomes. Seropositivity for H pylori was significantly associated with risk of short-term adverse outcomes, and independently predicted their incidence in multivariate regression (R = 3.05, p < 0.001). Results failed to show such an association between H pylori seropositivity and long-term adverse outcomes. H pylori infection may affect short-term prognosis in patients with ACS. Randomised trials are needed to evaluate the role of H pylori eradication in these patients.

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Citations

May 2, 2014·World Journal of Gastroenterology : WJG·Cong HeNong-Hua Lu
Feb 28, 2014·TheScientificWorldJournal·Jamshid VafaeimaneshMohammadreza Seyyedmajidi
May 13, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jacek BudzyńskiJacek Kubica
Sep 18, 2013·Helicobacter·Claire Roubaud BaudronAntonio Gasbarrini
Jul 27, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C-Y LaiC-H Kao
May 4, 2021·International Journal of General Medicine·Yoshitaka FurutoYuko Shibuya

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Methods Mentioned

BETA
coronary artery bypass
ELISA

Software Mentioned

SPSS

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